Home

Antiviral action of red algae-derived Carrageenans in case of experimental Hunt virus infection

27 May 2011
Written by Maksema I.G., Kompanets G.G., Barabanova A.O., Ermak I.M., Slonova R.A.

  UDK: [616.91‑002.151‑06:616.61]‑085.281:582.273 | Pages: 32–34 | Read full textDownload PDF 

Annotation:

The authors have studied antiviral action of Kappa type carrageenan and Lambda type carrageenan derived from Chondrus armatus algae in vitro during experimental Hunt virus infection and found out evident virus‑inhibiting action, given the high concentrations of Carrageenan of up to 1000–2000 mkg/ml. Given the lower concentrations (500 mkg/ml), the antiviral effects varied very much. In case of high levels, the Carrageenans were of low efficiency to inhibit viral reproduction during preliminary treatment with Vero E6 cells.

Links to authors:

I.G. Maksema, G.G. Kompanets, R.A. Slonova
Research Institute of Epidemiology and Microbiology of the Siberian Brach of Russian Academy of Medical Sciences (1 Selskaya St. Vladivostok 690087 Russian Federation)
A.O. Barabanova, I.M. Ermak
Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of Russian Academy of Sciences (159 100 Year Anniversary of Vladivostok Av. Vladivostok 690022 Russian Federation)

  1. 1. Bichurina M.A., Nikitina L.E., Sovetova M.G. et.al. Virus inhibi‑
    tory activity of the drug, made from mussel hydrolyzate, Vopr.
    virusol. 1994. No. 3. P. 134–136.
    2. Votjakov V.I., Boreko E.I. Approach to assessing the activity of
    chemical compounds against viruses propagated in material
    culture, Metod. vopr. nauchnoj razrabotki protivovirusnyh vewestv:
    tez. dokl. Minsk, 1977. P. 10–14.
    3. Ivanis V.A. Clinic, immunomodulating therapy of hemorrhagic
    fever with renal syndrome in the region of different serotypes
    of hantavirus circulation: synopsis, tethys, Vladivostok, 2004.
    52 p.
    4. Ivanis V.A., Maksema I.G., Afanaseva V.I., Slonova R.A. Clinical
    and immunological features of hemorrhagic fever with renal syn‑
    drome in severe with lethal and favorable outcome in Primorye,
    Pacific Medical Journal. 2010. No. 3. P. 46–51.
    5. Loginova S.Ja., Borisevich S.V., Kovalchuk A.V. et.al. Antiviral
    activity in vitro drug against the pathogen of hemorrhagic fever
    with renal syndrome, Voprosy virusologii. 2007. No. 6. P. 34–36.
    6. Maksema I.G., Makarenkova I.D. Antiviral activity of fucoidan
    natural origin in experimental infection with hantavirus, Pacific
    Medical Journal. 2008. No. 2. P. 86–89.
    7. Obrazcov Ju.G. Hemorrhagic fever with renal syndrome in the
    military of the Primorsky Krai (clinical and epidemiological
    characteristics and capabilities of causal therapy): synopsis, dis‑
    sertation. SPb., 2005. 20 p.
    8. Bourgougnon N. Anti‑HIV Compound from Red Seaweeds,
    Recent Advances in Marine Biotechnology (Fingerman M, Na‑
    gabhushanam R. eds). Sci. Publ. Inc. USA–UK. 2003. Vol. 9.
    P. 165–206.
    9. Deng H.Y., Luo F., Shi L.Q. et. al. Efficacy of arbidol on lethal
    hantaan virus infections in suckling mice and in vitro, Pharmacologica Sinica. 2009. No. 30. P. 1015–1024.
    10. Ghosh T., Chattopadhyay K., Marschall M. et al. Focus on antivirally
    active sulfated polysaccharides: From structure‑activity analysis to
    clinical evaluation, Glycobiology. 2009. Vol. 19. No. 1. P. 2–15.
    11. Lee P.W., Gibbs C. Jr., Gajdusek D., Yanagihara R. Serotypic classi‑
    fication of hantaviruses by indirect immunofluorescent antibody
    and plaque reduction neutralization tests, J. Clin. Microbiol. 1985.
    No. 22. P. 940–944.
    12. Reunov A., Nagorskaya V., Lapshina L. et al. Effect of κ/λ‑
    carrageenan from red a lga Tichocarpus crinitus (Tichocarpaceae)
    on infection of detached tobacco leaves with tobacco mosaic virus,
    J. Plant Diseases and Protection. 2004. Vol. 111. P. 165–172.
    13. Talarico L.B., Zibetti R.G., Faria P.C. Anti‑herpes simplex virus
    activity of sulfated galactans from the red seaweeds Gymnogon‑
    grus griffithsiae and Crytonmia crenulata, Int. J. Biol. Macromol.
    2005. Vol. 34. P. 63–71.
    14. Yermak I.M, Kim Y.H., Titlyanov E.A. et. al. Chemical structure
    and gel properties of carrageenan from a lgae belonging to the
    Gigartinaceae and Tichocapaceae, collected from the Russian
    Pacific coast, J. Appl. Phycol. 1999. Vol. 11. P. 41–48.
    15. Yermak I.M., Khotimchenko Yu.S. Chemical properties, biological
    activities and applications of carrageenan from red a lgae, Recent
    Advances in Marine Biotechnology (Fingerman M, Nagabhush‑
    anam R. eds). Sci. Publ. Inc. USA–UK. 2003. Vol. 9. P. 207–255. 

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.