Effects from Far Eastern Holothurians extract on oxidant-antioxidant balance and apoptosis in mice macrophages in case of experimental pseudotuberculosis infection

01 April 2011
Written by Dolmatova L.S., Zaika O.A., Timchenko N.F.

  UDK: [616.98:579.842.23‑06:616.94]‑085.324:563.96 | Pages: 53–56 | Read full textDownload PDF 


The paper describes effects from the Far Eastern Holothurians extract on nitroblue te‑trazolium production level and action of antioxidant ferments of mice macrophages infected with Yersinia pseudotuberculosis. As reported, given the 100% survival rate, 67% of infected animals had the peritoneal fluid coagulated. The three day introduction of HE into infected animals at the concentration of 0.5–1 mg/kg allowed to suppress functional activity of macrophages and have protective antiseptic effect, thereby decreasing a number of mice with septic manifestations. Given the 10 mg/kg dose, the Holothurians extract appeared to stimulate functional activity of macrophages and increase number of mice with coagulated perito‑
neal fluid. The authors suggest applying the Holothurians‑derived extract in low doses to treat septic manifestations in case of Yersiniosis.

Links to authors:

L.S. Dolmatova, O.A. Zaika
Pacific Oceanological Institute (43 Baltiyskaya St. Vladivostok 690041 Russian Federation)
N.F. Timchenko
Research Institute of Epidemiology and Microbiology of the Siberian Brach of Russian Academy of Medical Sciences (1 Selskaya St. Vladivostok 690087 Russian Federation)

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