Antioxidant properties of Chinese giant salamander skin secretion glycopeptides

25 March 2011
Written by Li W., Qu M., Tong Ch., Jin Q., Yu X., Wang W., Lukyanov P.A.

  UDK: 615.324.014.425:597.94:577.112.6 | Pages: 57–59 | Read full textDownload PDF 


The skin secretion of the Chinese giant salamander Andrias davidianus protects the ani‑mal from unfavourable environmental conditions, thus ensuring antioxidative resistance and protec‑tion from ultraviolet light. It prevents from bacterial infec‑
tions and has vulnerary effect. The glyco‑peptides with molecular weight of 3.5 kDa and lower have been extracted from the Chinese giant sal‑amander skin secretion. These are known to be resistant to 0.1 n of hydrochloric acid, trypsin and pepsin, easy to penetrate the intestinal wall. The glycopeptides have evident antioxidant properties, normalize nitroxide synthase activity of human peripheral blood, and suppress hyperproduction of reactive oxygen forms. It is very promising to treat oxidant stress.

Links to authors:

W. Li, Q. Jin, X. Yu, W. Wang 
Dalian Ocean University (Dalian Liaoning 116023 China)
M. Qu
Shenyang Agriculture University (Dalian Liaoning 116023 China),
Ch. Tong
Northeast Forestry University (Harbin eilongjiang 150040 China),
P.A. Lukyanov
Pacific Institute of Bioorganic Chemistry of the Far East Branch of Russian Academy of Science (159 100 Year Anniversary of Vladivostok Av. Vladivostok 690022 Russian Federation)

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