Polymorphism of interleukin-13 genes and xenobiotic detoxification systems in children with allergic pathology

27 May 2011
Written by Bakhaev D.B., Stenkova A.M., Ivanova Yu.V., Schegoleva O.V., Prosekova E.V., Rasskazov V.A., Isaeva M.P.

  UDK: 616‑056.43:577.22 | Pages: 63–65 | Read full textDownload PDF 


The paper provides results of interleukin‑13 genotyping with respect to three polymor‑phous locuses (–1512А>С, –1112С>Т and +2044G>A) as well as studies on zero‑polymorphism of genes M1 and T1 glutathione‑S‑transferase in children living in Vladivostok diagnosed with allergic diseases (73 patients) and allergic pathology‑free (27 patients). As reported, there are no evidences that the “zero” genotypes GSTM1 and GSTT1 cause allergic diseases. There has been considerable prevalence of heterozygous carrier state of 1112С/Т among the patients (58% against 22.2% in control). The heterozygous states were reliably more often observed simultaneously by 2 or 3 polymor‑phous locuses (48.4% against 18.5% in control) in children with clinical manifestations of the allergic diseases. The interleukin‑13 genotyping by three polymorphous locuses can be recommended for applying as additional criterion of risk groups for the allergic diseases.

Links to authors:

D.B. Bakhaev, A.M. Stenkova, V.A. Rasskazov, M.P. Isaeva
Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of Russian Academy of Sciences (159 100 Year Anniversary of Vladivostok Prospekt, Vladivostok, 690022 Russian Federation)
Yu.V. Ivanova, O.V. Schegoleva, E.V. Prosekova
Vladivostok State Medical University (2, Ostryakova Prospekt, Vladivostok, 690950 Russian Federation)

  1. Kaznacheev V.A., Gervaziev Ju.V. The role of cytokines gene
    polymorphisms and their receptors in the development of atopic
    asthma, Astma. 2004. Vol. 5, No. 1. P. 73–84.
    2. Frejdin M.B., Bragina E.Ju., Ogorodova L.M., Puzyrev V.P. [Glu‑
    tathione transferase gene polymorphism θ1 and μ1 (GSTT1 and
    GSTM1) in patients with atopic asthma in Western Siberia region,
    Molekuljarnaja biologija. 2002. Vol. 36, No. 4. P. 630–634.
    3. Frejdin M.B., Bragina E.Ju., Ogorodova L.M., Puzyrev V.P. The
    genetics of atopy: current status, Vestnik VOGiS. 2006. Vol. 10,
    No. 3. P. 492–503.
    4. Haitov R.M., Ilina N.I., Latysheva T.V. Rational pharmacotherapy
    of allergic diseases. M.: Litterra, 2007. 504 p.
    5. Cameron L., Webster R.B., Strempel J.M. et al. Th2‑selective en‑
    hancement of human IL‑13 transcription by IL‑13–1112C>T, a
    polymorphism associated with allergic inflammation, J. Immunol.
    2006. Vol. 177. P. 8633–8642.
    6. Eaton D.L. Concise Review of the Glutathione S‑Transferases
    and theig Significance to Toxicilogy, Toxicological sciences. 1999.
    Vol. 49. P. 154‑164.
    7. Georas S.N., Gue J., Fanis U.D., Casolaro V. T‑helper cell type‑2
    regulation in allergic disease, European respiratory journal. 2005.
    Vol. 26. P. 933–947.
    8. Graves P.E., Kabesch M., Halonen M. et al. A cluster of seven
    tightly linked polymorphisms in the IL‑13 gene is associated with
    total serum IgE levels in three populations of white children, J.
    Allergy Clin. Immunol. 2000. Vol. 105. P. 506–513.
    9. Heinzmann A., Mao X.Q., Akaiwa M. et al. Genetic variants of
    IL‑13 signalling and human asthma and atopy, Hum Mol Genet.
    2000. Vol. 9. P. 549–559.
    10. Islam T., Berhane K., McConnell R. et al. Glutathione‑S‑trans‑
    ferase (GST) P1, GSTM1, exercise, ozone and asthma incidence
    in school children, Thorax. 2009. Vol. 64. P. 197–202.
    11. Minelli C., Granell R., Newson R. et al. Glutathione‑S‑transferase
    genes and asthma phenotypes: a Human Genome Epidemiology
    (HuGE) systematic review and meta‑analysis including unpub‑
    lished data, Int. J. Epidemiol. 2010. Vol. 39. P. 539–562.
    12. Vavilin V.A., Safronova O.G., Lyapunova A.A. et al. Interaction
    of GSTM1, GSTT1, and GSTP1 genotypes in determination of
    predisposition to atopic dermatitis, Bull. Exp. Biol. Med. 2003.
    Vol. 136. P. 388–391.
    13. Vladich F.D., Brazille S.M., Stern D. et al. IL‑13 R130Q, a common
    variant associated with allergy and asthma, enhances effector
    mechanisms essential for human allergic inflammation, J. Clin.
    Invest. 2005. Vol. 115. P. 747–754.
    14. Wills‑Karp M., Luyimbazi J., Xu X. et al. Interleukin‑13: central
    mediator of allergic asthma, Sience. 1998. Vol. 282. P. 2258–2261.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.