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Polymorphism of interleukin-13 genes and xenobiotic detoxification systems in children with allergic pathology

27 May 2011
Written by Bakhaev D.B., Stenkova A.M., Ivanova Yu.V., Schegoleva O.V., Prosekova E.V., Rasskazov V.A., Isaeva M.P.

  UDK: 616‑056.43:577.22 | Pages: 63–65 | Read full textDownload PDF 

Annotation:

The paper provides results of interleukin‑13 genotyping with respect to three polymor‑phous locuses (–1512А>С, –1112С>Т and +2044G>A) as well as studies on zero‑polymorphism of genes M1 and T1 glutathione‑S‑transferase in children living in Vladivostok diagnosed with allergic diseases (73 patients) and allergic pathology‑free (27 patients). As reported, there are no evidences that the “zero” genotypes GSTM1 and GSTT1 cause allergic diseases. There has been considerable prevalence of heterozygous carrier state of 1112С/Т among the patients (58% against 22.2% in control). The heterozygous states were reliably more often observed simultaneously by 2 or 3 polymor‑phous locuses (48.4% against 18.5% in control) in children with clinical manifestations of the allergic diseases. The interleukin‑13 genotyping by three polymorphous locuses can be recommended for applying as additional criterion of risk groups for the allergic diseases.

Links to authors:

D.B. Bakhaev, A.M. Stenkova, V.A. Rasskazov, M.P. Isaeva
Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of Russian Academy of Sciences (159 100 Year Anniversary of Vladivostok Prospekt, Vladivostok, 690022 Russian Federation)
Yu.V. Ivanova, O.V. Schegoleva, E.V. Prosekova
Vladivostok State Medical University (2, Ostryakova Prospekt, Vladivostok, 690950 Russian Federation)

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