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Estimating systemic inflammatory response in patients with obliterating arterial sclerosis of lower limb arteries

26 April 2011
Written by Zaporozhets T.S., Maystrovsky K.V., Rapovka V.G., Ivanushko L.A., Smolina T.P., Gazha A.K.

  UDK: 616.137‑004.6‑002.18‑07 | Pages: 72–77 | Read full textDownload PDF 

Annotation:

The paper estimates efficiency of applying integral indices of inflammatory response – reactivity factor and reactivity level calculated upon the serum content of five cytokines (interleukins 6, 8 and 10, tumour necrosis factor‑α, and γ‑interferon) to describe chronic systemic inflammation in patients with obliterating atherosclerosis of the low limb arteries. As reported, the systemic inflamma‑tory response in this case is characterised by high levels of γ‑interferon and interleukin‑8, fibrinogen, markers of endothelium and leukocyte activation without participation of interleukin‑10‑depedent mechanisms, and organ dysfunction. When compared with the particular signs, the integral indices appear to be most efficient criteria to estimate systemic inflammatory response. The treatment re‑sistance of the chronic systemic inflammation in case of obliterating atherosclerosis requires optimis‑ing the pathogenetic anti‑inflammatory therapy. The method of assessing the chronic systemic in‑flammation using integral indices can be recommended to detect the systemic inflammatory response and its character, estimate risks of complications and monitor therapy of the obliterating atherosclero‑sis of lower limb arteries.

Links to authors:

T.S. Zaporozhets,  L.A. Ivanushko, T.P. Smolina, A.K. Gazha
Research Institute of Epidemiology and Microbiology of the Siberian Brach of Russian Academy of Medical Sciences (1 Selskaya St. Vladivostok 690087 Russian Federation)
K.V. Maystrovsky, V.G. Rapovka
Vladivostok State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)

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