Estimating systemic inflammatory response in patients with obliterating arterial sclerosis of lower limb arteries

26 April 2011
Written by Zaporozhets T.S., Maystrovsky K.V., Rapovka V.G., Ivanushko L.A., Smolina T.P., Gazha A.K.

  UDK: 616.137‑004.6‑002.18‑07 | Pages: 72–77 | Read full textDownload PDF 


The paper estimates efficiency of applying integral indices of inflammatory response – reactivity factor and reactivity level calculated upon the serum content of five cytokines (interleukins 6, 8 and 10, tumour necrosis factor‑α, and γ‑interferon) to describe chronic systemic inflammation in patients with obliterating atherosclerosis of the low limb arteries. As reported, the systemic inflamma‑tory response in this case is characterised by high levels of γ‑interferon and interleukin‑8, fibrinogen, markers of endothelium and leukocyte activation without participation of interleukin‑10‑depedent mechanisms, and organ dysfunction. When compared with the particular signs, the integral indices appear to be most efficient criteria to estimate systemic inflammatory response. The treatment re‑sistance of the chronic systemic inflammation in case of obliterating atherosclerosis requires optimis‑ing the pathogenetic anti‑inflammatory therapy. The method of assessing the chronic systemic in‑flammation using integral indices can be recommended to detect the systemic inflammatory response and its character, estimate risks of complications and monitor therapy of the obliterating atherosclero‑sis of lower limb arteries.

Links to authors:

T.S. Zaporozhets,  L.A. Ivanushko, T.P. Smolina, A.K. Gazha
Research Institute of Epidemiology and Microbiology of the Siberian Brach of Russian Academy of Medical Sciences (1 Selskaya St. Vladivostok 690087 Russian Federation)
K.V. Maystrovsky, V.G. Rapovka
Vladivostok State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)

  1. Gusev E.Ju., Chereshnev V.A., Jurchenko L.N. Systemic inflam‑
    mation on the position of typle pathological process, Citokiny i
    vospalenie. 2007. No. 4. p. 9–21.
    2. Gusev E.Ju., Jurchenko L.N., Chereshnev V.A., Zotova N.V. The
    methodology of the research of systemic inflammation, Citokiny
    i vospalenie. 2008. Vol. 7, No. 1. P. 15–25.
    3. Gusev E.Ju., Jurchenko L.N., Chereshnev V.A. et al. Chronical
    system inflammation as a typical pathological process, Citokiny
    i vospalenie. 2008. No. 4. P. 3–10.
    4. Koshkin V.M. Obliterating atheroscleros of the arteries of the
    lower limbs: the shortcomings and perspectives of conservative
    treatment, Klin. farmakol. i terapija. 2005. No. 4. P. 72–75.
    5. Kuznecov A.N. The modern signs treatment of the multifocal
    atherosclerosis. URL: http://www.pirogov‑centr.ru/infoclinic/2/6/
    (date – 10.03.2011).
    6. Pokrovskij A.V. Clinical angiology. M.: Medicina, 1979. 328 p.
    7. Savelev V.S, Koshkin V.M., Karalkin A.V. Pathogenesis and severe
    stages conservative treatment of atherosclerotic lesions of lower
    limbs arteries. M.: MIA, 2010. 214 p.
    8. Serik S.A., Stepanova, S.V., Volkov V.I. Pro‑and anti‑inflammatory
    cytokines in patients with ischemic heart disease with the pro‑
    gression of chronic heart failure. URL: http://www.rql.kiev.ua/
    cardio_j/2004/4/serik.htm (date 10.03.2011).
    9. Jurchenko L.N., Kuzmin V.V., Gusev E.Ju. et.al. Pathophysiologi‑
    cal phenomena of irreversible limb ischemia. Klin. anesteziol. i
    reanimatol. 2008. No. 4. P. 24–28.
    10. Chereshnev V.A., Gusev E.Ju., Jurchenko L.N. Systemic inflam‑
    mation – a myth or reality? Vestnik RAN. 2004. Vol. 74, No. 3.
    P. 219–225.
    11. Buono C., Come C.E., Stavrakis G. et al. Influence of interferon‑
    gamma on the extent and phenotype of diet‑induced atheroscle‑
    rosis in the LDLR‑deficient mouse, Arterioscler. Thromb. Vasc.
    Biol. 2003. Vol. 23. P. 454–460.
    12. Curtiss L.K., Tobias P.S.J. Emerging role of Toll‑like receptors in
    atherosclerosis, J. Lipid Res. 2009. Vol. 50. P. 340–345.
    13. Harvey E.J., Ramji D.P. Interferon‑gamma and atherosclero‑
    sis: pro‑ or anti‑atherogenic? Cardiovasc. Res. 2005. Vol. 67.
    P. 11–20.
    14. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis,
    Circulation. 2002. Vol. 105. P.1135–1143.
    15. Ranjbaran H. Sokol S., Gallo A. et al. An inflammatory pathway
    of IFNγ production in coronary atherosclerosis, J. of Immunology.
    2007. Vol. 178. P. 592–604.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.