Optimising estimation of parameters describing functional activity of innate immune cells in case of inflammatory lung diseases

01 April 2011
Written by Kondrashova N.M., Plekhova N.G., Somova L.M., Kostyushko A.V., Geltser B.I.

  UDK: 616.24‑002‑078:612.017.11 | Pages: 83–86 | Read full textDownload PDF 


The authors have applied their own method of estimating functional activity of innate immune cells in the areas of inflammation in an effort to optimise treatment of patients diagnosed with community‑acquired pneumonia. As confirmed, in order to identify the state of tissue immune response, it is expedient to examine functional activity of cells from induced sputum cells known to most actively respond to the bacterial agents. It is desirable to study a number of parameters of func‑tional activity of phagocytes and test their reserve capacities in order to improve objectiveness and reliability of the results. The proposed method allows to estimate effects from the treatment on the local defence of respiratory system, and therefore in a differentiated manner arrive at administering immunomodulating drugs.

Links to authors:

N.M. Kondrashova, A.V. Kostyushko, B.I. Geltser
Vladivostok State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)
N.G. Plekhova, L.M. Somova
Research Institute of Epidemiology and Microbiology of the Siberian Brach of Russian
Academy of Medical Sciences (1 Selskaya St. Vladivostok 690087 Russian Federation)

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