Progression of endothelial dysfunction during experimental hyperlipidemia

15 April 2011
Written by Turmova E.P., Lukyanov P.A., Grigoryuk A.A., Byihkov E.A., Tsyiulskiy A.V.

  UDK: 616.153.915:611.018.74:616.13‑004.6 | Pages: 97–100 | Read full textDownload PDF 


The authors evaluated the content of some cytokines, NADPH‑diaphorase and the indices of oxidative and anti‑oxidative activity in walls of aorta and femoral arteries of wistar rats during ex‑perimental hyperlipidemia. The levels of NADPH‑diaphorase in endothelium decreased. Both during the experiment and intact control, the level of interleukin‑4 in aorta was significantly lower than that in femoral artery. With the hyperlipidemia in femoral arteries, the authors have registered a decrease of interleukin‑4, but an increase of interleukin‑4 and y‑interferon and decrease of oxidative and anti‑oxidative activity with low oxidative index in the aorta wall. The authors prove a stimulating effect of interleukin‑4 and inhibitory action of y‑interferon upon general oxidative and antioxidative activity in the wall of aorta.

Links to authors:

E.P. Turmova, A.A. Grigoryuk, E.A. Byihkov
Vladivostok State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)
P.A. Lukyanov
Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences (159 100 Year Anni-versary of Vladivostok Av. Vladivostok 690022 Russian Federation)
A.V. Tsyiulskiy
Far Eastern Federal University (8 Suhanova St. Vladivostok 690091 Russian Federation)

  1. Vorobeva E.N., Shumaher G.I., Osipova I.V. et.al. The role of en‑
    dothelial dysfunction in the pathogenesis of atherosclerosis, Kardiovaskuljarnaja terapija i profilaktika. 2006, No. 5 (6). P. 129–136.
    2. Zotova I.V., Zatejwikov D.A., Sidorenko B.A. Synthesis of nitric
    oxide and the development of atherosclerosis, Kardiologija. 2002,
    No. 4. P. 57–67.
    3. Kozlov V.A., Dushkin M.I., Verewagin E.I. Vaccine against ath‑
    erosclerosis: Facts and Perspectives, Citokiny i vospalenie. 2008.
    No. 1. P. 8–13.
    4. Lupach N.M., Hludeeva E.A., Lukjanov P.A. et.al. Matrix metal‑
    loproteinases, oxidative status and endothelial dysfunction with
    hiperholestrinemy in patients with various forms of ischemic heart
    disease, Rossijskij medicinskij zhurnal. 2010, No. 4. P. 71–74.
    5. Mewerskaja K.A., Borodina G.P., Koroleva N.P. About the method
    of agents selection, affecting on the cholesterol metabolism, Jeleuterokokk i drugie adaptogeny iz dalnevostochnyh rastenij / ed. K.A.
    Mewerskoj. Vladivostok, 1966. P. 289–294.
    6. Cytokine system: theoretical and clinical aspects / ed. V.A. Ko‑
    zlova, S.V. Sennikova. Novosibirsk: Nauka, 2004. 324 p.
    7. Titov V.N. The generality of atherosclerosis and inflammation:
    the specificity of atherosclerosis as an inflammatory process
    (hypothesis), Klinicheskaja laboratornaja diagnostika. 2006. No.
    4. P. 310.
    8. Haitov R.M. Immunology. Normal and pathological conditions:
    a textbook. M.: Medicina, 2010. 752 p.
    9. Shumatova T.A., Prihodchenko N.G., Grigorjan L.A. et.al. Ni‑
    troxidergic mechanisms in the pathogenesis of persistent diar‑
    rhea in infants in the first year, Pacific Medical Journal. 2010. No.
    3. P. 59–61.
    10. Shljahto E.V., Gavrisheva N.A., Ovchinnikova O.A. et.al. The
    effect of inflammation induction on the metabolism of collagen
    in atherosclerotic plaques in mouse, Medicinskaja immunologija.
    2008. No. 6. P. 507–512.
    11. Allison B.R., Amy D.G. Atherosclerosis: immune and inflam‑
    matory aspects, Journal of investigative medicine. 2006. Vol. 54,
    No. 3. P.123–131.
    12. Huber S.A., Sakkinen P., David C. T‑helper‑cell phenotype regu‑
    lates atherosclerosis in mice under conditions of mild hypercho‑
    lesterolemia, Circulation. 2001. No. 103. P. 2610–2616.
    13. Georg J., Shoenfeld Y. Requisite role for interleukin‑4 in the
    acceleration of fatty streaks induced by heat shock protein 65
    of Mycobacterium tuberculosis, Circ. Res. J. 2000. No. 86. P.
    14. Park I.K., Son H., Kim S.W., Paick J.–S. Initial validation of a novel
    rat model of vasculogenic erectile dysfunction with generalized
    atherosclerosis International, Journal of Impotence Research. 2005.
    Vol.17. P. 424–430.


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