Structure of neuropsycological defect of disseminated sclerosis patients

26 May 2011
Written by Korotkova M.A., Gulaeva S.E., Ovchinnikova A.A., Ovchinnikov A.V.

  UDK: 616.832‑004.2:616.89‑008.6 | Pages: 101–103 | Read full textDownload PDF 


The authors have studied the structure of neuropsycological defect of 86 patients with various types of the course of cerebrospinal disseminated sclerosis. Regardless of the course type, the core of psychopathologic disorders is composed of triad of symptoms, among which are cognitive deficiency, emotional‑volitional disorders, and vegetative disfunctions. The cognitive deficiency comes from disorder of motor control. The emotional‑volitional disorders are characterized by forming of anxiodepressive states, while the vegetative disfunctions cover the utter variety and lability of manifestations. The degree of manifestations of psychopathologic defect depends on the disease state and location of demyeliniation focuses. The destruction of ties in the systems supporting control over regulation of mental activity, which are suprasegmental vegetative apparatus, plays a key role in the development of psychological deficiency.

Links to authors:

M.A. Korotkova, S.E. Gulyaeva, A.A. Ovchinnikova, A.V. Ovchinnikov
Vladivostok State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)

  1. Alekseeva T.G., Bojko A.N., Gusev E.I. The spectrum of neurop‑
    sychological symptoms in multiple sclerosis, Zhurn. psihiatrii.
    2000. No. 100. P. 15.
    2. Gusev E.I., Bojko A.N. Multiple sclerosis: from study of immu‑
    nopathogenesis to new treatments. M.: Gubernskaja medicina,
    2001. 543 p.
    3. Gusev E.I., Bojko A.N., Smirnova N.F. Risk factors for multiple
    sclerosis in the Moscow population. I. Exogenous risk factor,
    Zhurn. nevrologii i psihiatrii. 1999. No. 5. P. 32–40.
    4. Gusev E.I., Bojko A.N., Demina T.L. Risk factors for multiple
    sclerosis in the Moscow population. II. The combination of ex‑
    ogenous and genetic factors, Zhurn. nevrologii i psihiatrii. 1999.
    No. 6. P. 47–52.
    5. Gusev E.I., Demina T.L., Bojko A.N. Multiple sclerosis. M.: Neft
    i gaz, 1997. 463 p.
    6. Krotenko N.V. Indicators of oxidative stress in different types of
    MS disease: abstracts. Irkutsk, 2011. 22 p.
    7. Markina O.L. Clinical features of multiple sclerosis in relation
    to structural and functional changes in lymphocyte membranes:
    abstract. Novosibirsk, 2005. 24 p.
    8. Hohlfeld R. Biottchnologica agents for the immunotherapy of
    multiple sclerosis. Principles problems and perspectives [ Invited
    review], Brain. 1997. Vol. 120. P. 865–916.
    9. Lucchinetti C., Brueck W., Rodriguez M. Distinct patterns of mul‑
    tiple sclerosis pathology indicates heterogeneity in pathogenesis,
    Brain Pathol. 1996. Vol. 6. P. 259–274.
    10. Mohr D.S., Goodkin D.E., Bacchetti P. Psychological stress and
    the subsequent appearance of new brain MRL lesions in MS //
    Neurology. 2000. Vol. 55. P. 55–61.
    11. Multiple sclerosis / eds D. Paty, G.S. Ebers. Philadelphia: FA Dav.
    Comp., 1998. 572 p.


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