Home

Estimating dynamics of apoptosis and its regulation in case of maxillary sinus

Written by Edranov S.S., Tsoy V.G., Kheteeva I.M

  UDK: 616.216.1‑001: 616‑081.818 | Pages: 12-15 | Full text PDF | Open PDF 

Annotation:

The paper overviews results of authors’ studies into
molecular mechanisms of apoptosis and its role in reparation
of mucous coat after deafferentation and mechanical injury of
maxillary sinus. The progression of apoptosis, extent of produc‑
tion of nitric oxide, p53 and Bcl‑2 in mucous cells appear to be
interdependent. The nitric oxide is capable of showing pro‑ and
anti‑apoptogenic effects in different periods after injury. These
processes result in the reduction of secondary injury of cells due
to nitric oxide effects on apoptosis and stimulation of trophic and
regeneration‑related capabilities of the mucous coat. The inhibi‑
tion of apoptosis can facilitate the regeneration processes. The
stimulation of apoptosis in future may exhibit cytoprotective ef‑
fects in case of secondary injury of inflammatory products.

Links to authors:

S.S. Edranov, V.G. Tsoy, I.M. Kheteeva
S.S. Edranov
Vladivostok State Medical University (2 Ostryakova Av.Vladivostok 690950 Russian Federation)
V.G. Tsoy
Mobile Surgical Team Co Ltd. (17 Avrorovskaya St. Vladivostok 690078 Russian Federation)
I.M. Kheteeva
Dental Clinic ‘Almaz’ (35 Davidov St. Vladivostok 690105 Russian Federation)

  1. 1. Edranov S.S. Apoptosis as a factor in the organization of post‑
    traumatic inflammation // Pacific Medical Journal. 2012. No. 2.
    P. 100–104.
    2. Edranov S.S. Mast cell nitric oxide synthase maxillary of sinus
    mucosa of rats with injury to the maxillary nerve // Pacific Medi‑
    cal Journal. 2011. No. 4. P. 53–56.
    3. Edranov S.S., Kovaleva I.V., Krjukov K.I., Konovko A.A., Ana‑
    tomical and histological study of the maxillary researches white
    rat // Bulletin of Experimental Biology and Medicine. 2004.
    No. 12. P. 680–683.
    4. Edranov S.S., Motavkin P.A. Apoptosis as a mechanism of maxil‑
    lary sinus mucosa injury of rats with experimental injury to the
    maxillary nerve // Bulletin of Experimental Biology and Medicine.
    2012. Vol. 153, No. 4. P. 518–522.
    5.Kalinichenko S.G., Matveeva N.U. Morphological characteristics
    of apoptosis and its significance in neurogenesis // Morphology.
    2007. Vol. 131, No. 2. P. 16–28.
    6. Lushnikov E.F., Abrosimov A.U. Cell death (apoptosis). M.:
    Medicine, 2001. 190 p.
    7. Matveeva N.U., Kalinichenko S.G., Pushin I.I., Motavkin P.A.
    Role of nitric oxide in the apoptosis of retinal neurons human
    fetuses // Morphology. 2006. Vol. 123, No. 1. P. 40–49.
    8. Palcev M.A. The molecular basis of apoptosis // Journal of RAMS.
    2002. Vol. 72, No. 1. P. 13–21.
    9. Filchenkov A.A. The caspase: regulators of apoptosis and other
    cellular functions // Biochemistry. 2003. No. 68. P. 453–466.
    10.Yarilin A.A. The apoptosis. The nature of the phenomenon and
    its role in the whole organism // Pathological physiology. 1998.
    No. 2. P. 38–48.
    11.Chae I.H., Park K.W., Kim H.S., Oh B.H. Nitric oxide‑induced
    apoptosis is mediated by Bax/Bcl‑2 gene expression, transition of
    cytochrome c, and activation of caspase‑3 in rat vascular smooth
    muscle cells // Clin. Chim. Acta. 2004. Vol. 341. P. 83–91.
    12.Chung E.Y., Kim S.J., Ma X.J. Regulation of cytokine production
    during phagocytosis of apoptotic cells // Cell Research. 2006.
    Vol. 16. P. 154–161.
    13. Dubikov A.I., Kalinichenko S.G. Small molecules regulating
    apoptosis in the synovium in rheumatoid arthritis // Scand. J.
    Rheumatol. 2010. Vol. 39. P. 368–372.
    14. Ferri K. Apoptosis control in syncytia induced by thy HIV type
    1‑envelope glycoprotein complex, role of mitochondria and cas‑
    pase // J. Exp. Med. 2000. Vol. 192. P. 1081–1092.
    15.Hengarten O.M. The biochemistry of apoptosis // Nature. 2000.
    Vol. 407. P. 770–775.
    16.Ho P.K., Hawkins C.J. Mammalian initiator apoptotic caspases //
    FEBS J. 2005. Vol. 272. P. 5436–5453.
    17.Horky M., Kotala V., Anton M. et al. Nucleolus and apoptosis //
    Ann. N.Y. Acad. Sci. 2002. Vol. 973. P. 258–264.
    18.Ju E.J., Kwak D.H., Lee D.H. et al. Pathophysiological implica‑
    tion of ganglioside GM3 in early mouse embryonic develop‑
    ment through apoptosis // Arch. Pharm. Res. 2005. Vol. 28.
    P. 1057–1064.
    19.Kuida K., Haydar T., Kuan C. et al. Reduced apoptosis and cyto‑
    chrome c‑mediated caspase activation in mice lacking caspase 9
    // Cell. 1998. Vol. 94. P. 352–337.
    20. Meier P., Finch A., Evan G. Apoptosis in development // Nature.
    2000. Vol. 407. P. 796–801.
    21. Moll U.M., Zaika A. Nuclear and mitochondrial apoptotic path‑
    ways of p53 // FEBS Lett. 2001. Vol. 493. P. 65–69.
    22. Muresanu D.F. Neurotrophic factors. Bucuresti: Libripress,
    2003.464 p.
    23. Neary J.T., Zimmermann H. Trophic functions of nucleotides
    in the central nervous system // Trends Neurosci. 2009. Vol. 32.
    P. 189–198.
    24. Niidome T., Morimoto N., Iijima S. et al. Mechanisms of cell death
    of neural progenitor cells caused by trophic support deprivation
    // Eur. J. Pharmacol. 2006. Vol. 548. P. 1–8.
    25. Oppenheim R.W. Programmed cell death // Fundamental Neu‑
    roscience / Zigmond M.J., Bloom F.E., Roberts J.L. et al., eds. San
    Diego: Academic, 1999. P. 581–609.
    26. Perecko T., Drabikova K., Rackova L. et al. Molecular targets of
    the natural antioxidant pterostilbene: effect on protein kinase C,
    caspase‑3 and apoptosis in human neutrophils in vitro // Neu‑
    roendocrinol. Lett. 2010. Vol. 28. P. 34–38.
    27. Skulachev V.P., Bakeeva L.E., Chernyak B.V. et al. Thread‑grain
    transition of mitochondrial reticulum as a step of mitoptosis
    and apoptosis // Molecular and Cellular Biochemistry. 2004.
    Vol. 256–257. P. 341–358.
    28. Sloviter R. Apoptosis: a guide for perplexed // Trends Pharmacol
    Sci. 2002. Vol. 23. P. 19–24.
    29. Van Delft M.F., Huang D.C. How the Bcl‑2 family of proteins
    interact to regulate apoptosis // Cell Research. 2006. Vol. 16.
    P. 203–213.
    30.Yan N., Shi Y. Mechanisms of apoptosis through structural biol‑
    ogy // Annual Review of Cell and Developmental Biology. 2005.
    Vol. 21. P. 35–56. 

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.