Estimating dynamics of apoptosis and its regulation in case of maxillary sinus

Written by Edranov S.S., Tsoy V.G., Kheteeva I.M

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The paper overviews results of authors’ studies into
molecular mechanisms of apoptosis and its role in reparation
of mucous coat after deafferentation and mechanical injury of
maxillary sinus. The progression of apoptosis, extent of produc‑
tion of nitric oxide, p53 and Bcl‑2 in mucous cells appear to be
interdependent. The nitric oxide is capable of showing pro‑ and
anti‑apoptogenic effects in different periods after injury. These
processes result in the reduction of secondary injury of cells due
to nitric oxide effects on apoptosis and stimulation of trophic and
regeneration‑related capabilities of the mucous coat. The inhibi‑
tion of apoptosis can facilitate the regeneration processes. The
stimulation of apoptosis in future may exhibit cytoprotective ef‑
fects in case of secondary injury of inflammatory products.

Links to authors:

S.S. Edranov, V.G. Tsoy, I.M. Kheteeva
S.S. Edranov
Vladivostok State Medical University (2 Ostryakova Av.Vladivostok 690950 Russian Federation)
V.G. Tsoy
Mobile Surgical Team Co Ltd. (17 Avrorovskaya St. Vladivostok 690078 Russian Federation)
I.M. Kheteeva
Dental Clinic ‘Almaz’ (35 Davidov St. Vladivostok 690105 Russian Federation)

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