Research of cytokine profile before and after dental implantation

Written by Yugay Yu.V., Tolmachev V.E., Markelova E.V., Golitsyna A.A

  UDK: 616.314‑089.843:612.017 | Pages: 31-33 | Full text PDF | Open PDF 


The authors have measured the cytokine levels (tu‑
mour necrosis‑ α factor, interleukins 1β, 4 and 6) in blood serum
and oral fluid before and after dental implantation in 30 patients
aged 30–60 years old, and compared the indices obtained in case
of non‑complicated post‑surgery period (20 patients) and during
the post‑surgery period complicated with mucositis (10 patients).
After implantation, there was a significant increase of the tumour
necrosis‑α factor at the local and system levels. During the post‑
operative period, the content of interleukin‑1β in oral fluid con‑
siderably exceeded the level of other cytokines. The local cytokine
profile in patients with complicated course of the post‑operative
period was mostly characterised by increased level of interleukin‑6
and insufficient content of interleukin‑4. As reported, the level of
interleukin‑4 in saliva of over 4 pg/mL may be indicative of compli‑
cated dental implantation.

Links to authors:

Yu.V. Yugay, V.E. Tolmachev, E.V. Markelova, A.A. Golitsyna
Vladivostok State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)

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