The state of oral cavity in patients with inflammatory bowel diseases according to functional and laboratory screening

Written by Tsimbalistov A.V., Robakidze N.S., Tyityuk S.Yu.

  UDK: 616.31‑002‑06:616.34‑002‑07 | Pages: 51-53 | Full text PDF | Open PDF 


The medical examination of 80 patients with inflamma‑
tory bowel diseases allowed to detect the high occurrence of dental
pathology like chronic catarrhal and chronic recurrent aphthous
stomatitis, inflammatory diseases of paradontium, and find out he‑
modynamic disorders in paradontium and oral mucosa at different
levels. The authors have pointed out the imbalance between pro‑
inflammatory and anti‑inflammatory cytokines in oral fluid and
high occurrence of Epstein‑Bar viral infection that is indicative of
the imbalance of local immunity factors. These changes may be re‑
sponsible for high occurrence of dental pathology in patients with
chronic cicatrizing enteritis and ulcerative colitis.

Links to authors:

A.V. Tsimbalistov, N.S. Robakidze, S.Yu. Tyityuk
North-Western State Medical University named after I.I. Mechnikov (41 Kirochnaya St. Saint-Petersburg 198302 Russian Federation)

  1. 1.Adler G. Crohns disease and ulcerative colitis / translated from
    the German. M.: GJeOTAR‑Med., 2001. 527 p.
    2.Antonova I.N. The role of professional oral hygiene in the complex
    approach to diagnostic and treatment of inflammatory parodontal
    diseases: the thesis. SPb., 2000. 17 p.
    3. Baranovskii A.U., Simanenkov V.I. The achievements and
    prospects of the functional and inflammatory bowel diseases
    in St. Petersburg MAPE // Bulletin of MAPE. 2010. No. 2.
    P. 121–134.
    4. Grudyanov A.I., Grigoryan A.S., Frolova O.A. Diagnostics in
    periodontology. M.: MIA, 2004. 49 p.
    5.Ketlinskii S.A., Simbircev A.S. The cytokines. SPb.: Foliant, 2008.
    552 p.
    6. Neizberg D.M., Levin M.L. Characteristics of the oral cavity lo‑
    cal immunity of patients with gastrointestinal tract diseases //
    Proceedings of the VII Conference of Maxillofacial Surgeons and
    Dentists. SPb., 2001. P. 80–81.
    7. Gibson J., Wray D., Bagg J. Oral staphylococcal mucositis:
    A new clinical entity in orofacial granulomatosis and Crohn’s
    disease // Oral Surg. Oral Med. Oral Pathol. 2000. Vol. 89,
    No. 2. P. 171–176.
    8.Ishiguro Y. Mucosal proinflammatory cytokine production cor‑
    relates with endoscopic activity of ulcerative colitis // J. Gastroen‑
    terology. 1999. Vol. 34, No. l. P. 66–74.
    9.Wright S., Sanders D.S., Lobo A.J. et al. Clinical significance of
    azathioprine active metabolite concentrations in inflammatory
    bowel disease // Gut. 2004. Vol. 53, No. 8. P. 1123–1128. 


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.