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Role of DNA methylation and folate metabolism in the development of pathological processes in the human body

Written by Shumatova T.A., Prikhodchenko N.G., Odenbakh L.A., Efremova I.V.

  Индекс УДК: 616‑057.7:577.213/.217 | Страницы: 39-43 | Полный текст статьи. PDF файл | Открыть PDF 

Аннотация:

The review was devoted the current understanding of the role of DNA methylation in the physiology and pathology of the human body. It was revealed the influence of genotype on epigenotype, the factors that trigger and suppress the processes of DNA methylation and histone deacetylation, the role of the state of folate metabolism in the development of pathological processes. Special attention was paid to the role of genes encoding enzymes of folate cycle, since lack of methyl groups directly linked to polymorphisms in these genes. It was shown that poly‑morphic variants of genes MTHFR, MTRR and MTR, causing different functional significance of protein products affect a wide range of biochemical reactions in the folate cycle, and, according to some authors, can be regarded as a risk factor for a number of diseases.

Ссылки на авторов:

T.A. Shumatova, N.G. Prikhodchenko, L.A. Odenbakh, I.V. Efremova
Pacific State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)

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