The inhibiting effect of photodynamic therapy and novel recombinant human endostatin on the in vivo growth of U251 human glioma xenografts

Written by Hu Shaoshan, Zhan Qi, Yue Wu

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Endostar, a novel recombinant human endostatin expressed in Escherіchіa coli, was approved by the State FDA in China. To investigate the effect of endostar and photodynamic therapy (PDT) on the in vivo growth of U251 glioma. Seven days after inoculation with U251 cells, nude mice with MRI‑confirmed glioma were randomly assigned to 4 groups: PDT+endostar group; PDT group; endostar group and control group. In the PDT group, survival prolonged, accompanied by an increase in apoptosis, when compared with the control group. Furthermore, these changes were more pronounced in the PDT+endostar group. After PDT, hypoxia inducible factor‑1α (HIF‑1α) and vascular endothelial growth factor A (VEGF‑A) expression was markedly increased and after endostar treatment, HIF‑1α and VEGF‑A expression was significantly reduced. PDT, in combination with endostar, can significantly inhibit the growth of U251 glioma. This approach may represent a promising strategy in the treatment of malignant tumors.

Ссылки на авторов:

Hu Shaoshan
Second Affiliated Hospital
Zhan Qi, Yue Wu
Fourth Affiliated Hospital of Harbin Medical University (157 Baojian Road, Nangang District, Harbin 150081 P.R. China)

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