New mechanisms of osteoporosis formation in case of terminal lung disease

Written by Kochetkova E.A., Ugay L.G., Maystrovskaya Yu.V., Nevzorova V.A., Frossard N., Massard J.

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The authors have examined 47 patients aged 36–64 waiting for lung transplantation to study relations between the adipokine level, expression of leptin and adiponectin receptors in fatty tissue and bone mineral density in case of terminal lung disease. As reported, there is a correlation between the bone mineral density and levels of lectin, adiponectin and resistin in blood serum. The tumour necrosis factor alpha concentration has been inversely related to the bone mineral density, and its receptor levels have exceeded the normal range in patients with terminal lung disease. The patients under examination had the leptin receptor activity decreased and the adiponectin receptor activity increased in skin and subcutaneous fat. Additionally, the studies have allowed to identify a relationship between the morphofunctional skin changes and striped muscles and the adipokine receptor activity and the intensity of osteopenic syndrome in patients with terminal lung disease.

Ссылки на авторов:

E.A. Kochetkova, L.G. Ugay, Yu.V. Maystrovskaya, V.A. Nevzorova
Pacific State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)
N. Frossard, J. Massard
Louis Pasteur University, Strasbourg (4 Rue Blaise Pasca CS 90032 lF-67070 Strasbourg Cedex France)

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