Genetic polymorphism of thrombophilia in patients with pulmonary artery thromboembolism in Primorsky Krai

Written by Kinyaikin M.F., Naumova I.V., Buyakova E.D., Bulasheva A.V., Rozhnova E.A., Kuraspediani O.V

  Индекс УДК: 616.151.5:616.131‑005.7(571.63) | Страницы: 79-81 | Полный текст статьи. PDF файл | Открыть PDF 


The paper analyses genetic polymorphism of thrombophilia in 68 patients with thromboembolia of the pulmonary artery (PATE) in Pimorsky Krai. The polymorphisms in genes associated with the risk factors for thrombophilia and venous thromboembolic complications was somewhat distinctive in comparison with that of
the European population, and, foremost, it was represented by mutations in genes of folate cycle (97.1 % of cases) and disorders related to plasminogen activator inhibitor type 1 gene (88.2 % of cases). The genetic predisposition to hyperaggregation of platelets was recorded in more than half of the patients (55.9 %). The synergism of thrombosis risk factors was observed in all PATE cases. These changes shall be allowed for when developing programs for secondary prevention of venous thromboembolic complications. The therapy shall be continuous and likely to last throughout the life, and include drugs known to have effect on different coagulation system components, based upon both laboratory findings that are indicative of haemostatic disorders, and foremost, molecular genetic testing results.

Ссылки на авторов:

M.F. Kinyaikin, I.V. Naumova
Pacific State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)
Primorsky Regional Clinical Hospital No. 1 (57 Aleutskaya St. Vladivostok 690091 Russian Federation)
E.D. Buyakova, A.V. Bulasheva, E.A. Rozhnova, O.V. Kuraspediani
Primorsky Regional Clinical Hospital No. 1 (57 Aleutskaya St. Vladivostok 690091 Russian Federation)

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