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Genetic polymorphism of thrombophilia in patients with pulmonary artery thromboembolism in Primorsky Krai

Written by Kinyaikin M.F., Naumova I.V., Buyakova E.D., Bulasheva A.V., Rozhnova E.A., Kuraspediani O.V

  Индекс УДК: 616.151.5:616.131‑005.7(571.63) | Страницы: 79-81 | Полный текст статьи. PDF файл | Открыть PDF 

Аннотация:

The paper analyses genetic polymorphism of thrombophilia in 68 patients with thromboembolia of the pulmonary artery (PATE) in Pimorsky Krai. The polymorphisms in genes associated with the risk factors for thrombophilia and venous thromboembolic complications was somewhat distinctive in comparison with that of
the European population, and, foremost, it was represented by mutations in genes of folate cycle (97.1 % of cases) and disorders related to plasminogen activator inhibitor type 1 gene (88.2 % of cases). The genetic predisposition to hyperaggregation of platelets was recorded in more than half of the patients (55.9 %). The synergism of thrombosis risk factors was observed in all PATE cases. These changes shall be allowed for when developing programs for secondary prevention of venous thromboembolic complications. The therapy shall be continuous and likely to last throughout the life, and include drugs known to have effect on different coagulation system components, based upon both laboratory findings that are indicative of haemostatic disorders, and foremost, molecular genetic testing results.

Ссылки на авторов:

M.F. Kinyaikin, I.V. Naumova
Pacific State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)
Primorsky Regional Clinical Hospital No. 1 (57 Aleutskaya St. Vladivostok 690091 Russian Federation)
E.D. Buyakova, A.V. Bulasheva, E.A. Rozhnova, O.V. Kuraspediani
Primorsky Regional Clinical Hospital No. 1 (57 Aleutskaya St. Vladivostok 690091 Russian Federation)

  1. Barkagan Z. S., Momot A. P. Diagnostics and controlled therapy of hemostasis disturbances [the 2nd edition supplemented] M.: Newdiamed, 2001. 296 p.
  2. Kalashnikova E.A., Kokarovtseva S.N., Kovalenko T. F. [et al.] Mutation frequency in genes of the V factors (FV Leiden), prothrombin (G20210A) and 5.10 methylene‑tetra‑hydro‑folate‑reductase (C677T) in Russians // Medical genetics. 2006. Vol. 5, No. 7. P. 27–29.
  3. Kapustin V.M., Blinov M.N., Kargin V.D. [et al.] Genetic determinants of hereditary thrombophilia in pathogenesis venous thrombosis // Ter. archive. 2003. No. 10. P. 78–80.
  4. Kirienko A.I., Panchenko E.P., Andriyashkin V.V. Venous thrombosis in the practice of physician and surgeon. M.: Planida, 2012. 336 p.
  5. Minutes of All‑Russian register “Genetic risk factors of thrombosis in dwellers within the territory of Russia, clinical phenotyping and thrombus prevention of inopectic disturbances in ontogenesis” // Thrombosis, hemostasis and rheology. 2010. No. 3 (43). P. 30–78.
  6. Rovenskikh D.N., Maksimov N.M., Tatarnikova N.P. [et al.] The role of molecular‑genetic factors in the risk of development of acute thrombosis in lower extremities’ deep veins // URL: http://_kk.convdocs.org/docs/index‑63541.html (application date: 2013/03/09).
  7. Russian clinical recommendations on diagnostics, treatment and prevention of venous inopectic complications // Association of Russian phlebologists, All‑Russian society of surgeons. M.: Media Sfera, 2010. 54 p.
  8. Tadtaeva Z.G., Katsadze Yu.L. Polymorphism of the gene of methylene‑tetra‑hydro‑folate‑reductase, hyperhomocysteinemia and possibilities of its drug correction with neuromultivit in children’s hemicrania // Kazan medical journal. 2007. No. 1. P. 16–20.
  9. Shmeleva V.M. Hyperhomocysteinemia as important risk factor in development of arterial and venous thrombosis in North‑West territory of Russia // Thrombosis, hemostasis and rheology. 2002. No. 1. P. 154–159.
  10. Shpolyanskaya N.Yu., Ozolinya L.A., Patrushev L.I. [et al.] High frequency of Leiden mutation in patients with venous inopectic complications in obstetrics and gynecology // URL:www. hemostas. ru/society/publications/P.13.shtml (application date: 2013/03/09).
  11. Yakovlev V.B., Yakovleva M.V. Venous inopectic complications: diagnostics, treatment and prevention // Russian medical news. 2002. Vol. 7, No. 2. P. 4–18.
  12. Balta G., Altay C., Gurgey A. PAI‑1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs // Am. J. Hematol. 2002. Vol. 71, No. 2. P. 89–93.

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