Magnetic resonance imaging in hepatolenticular degeneration diagnosis

Written by Ovchinnikov A.V.

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The paper provides results of clinical examination and magnetic resonance imaging (MRI) of 55 patients with neurologic symptoms of hepatolenticular degeneration (HLD), and determines that the MRI‑derived cerebral changes are not specific in case of hepatolenticular degeneration. Four types of images are deemed to be most representative. These are lacking changes, occurrence of altered density focuses to be mainly detected in basal ganglia, cortical atrophy, and brain structural abnormalities. It is assumed that the visualisation of brain anatomical structure abnormalities of relatively frequent occurrence is most likely to be indicative of early prenatal manifestations of congenital transmission of defective metabolism known to disturb formation of cerebral tissue structures long before the clinical symptoms of hepatolenticular degeneration occur. The author has failed to identify clear correlations between the clinical symptoms of hyperkinesis
and the MRI‑derived indices.

Ссылки на авторов:

A.V. Ovchinnikov
Pacific State Medical University (2 Ostryakova Av. Vladivostok 690950 Russian Federation)

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