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Nox induced early dismetaboly of the articular cartilage caused by the intra-articular fractures

Written by Cherepovskiy A.V., Shulepin I.V.

  UDK: 616.718.5-001.5:612.128 | Pages: 42–44 | Full text PDF | Open PDF 

Annotation:

Background. Analysis of activity of the NO synthase (NOS) of the articular cartilage of the knee joint as a result of the intra-articular fractures of the lateral condyle of thibia.
Methods. The NADPH-diaphorase analysis of the hematoxylin and eosin and toluidine blue imbued tissue samples out of the core of lateral condyle of the tibia during operations for osteosynthesis on 15 intra-articular fractures patients.
Results. Elicited a statistically significant increment in activity of the NOS of the chondrocytes in the course of the rehabiltation along with a valid decrement in amount of glycosaminoglycans in cartilage matrix. The given changes available subject to the structural intgrity of the cartilage or in the early period of presence of an isolated osteochondral fragment after impression fracture.
Conclusions. The intra-articular fractures cause an early defect of anabolism of the cartilage related with an increment in activity of the NOS. The optimal period of an operation for osteosynthesis may be within 7–10 days after an injure before degradation of the functional potency of a cartilage.

Links to authors:

A.V. Cherepovskiy1, I.V. Shulepin2
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)
2 Vladivostok clinical hospital No. 2 (57 Russkaya St. Vladivostok 690105 Russian Federation)

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