Osteoarthritis and microcrystalline stress phenomenon

Written by Kabalyk M.A., Dubikov A.I., Petrikeeva T.Y., Karabtsov A.A., Kuzmin I.I., Cherepovskiy A.V

  UDK: 616.718.4-02:577.118: 616.72-018.3 | Pages: 70–74 | Full text PDF | Open PDF 


Background. The importance of the phenomenon of mineralization of cartilage due to osteoarthritis (OA) proved by an evidence of factors contributing to this process. The object of this study is to determine the clinical and pathogenetic significance of microcrystallisation of the articular cartilage caused by OA.
Methods. The study embraced 110 persons operated on coxarthrosis from II to IV grades by (osteoarthritis grading system of) Kellgren and Lawrence and 50 persons undergone hip replacement after a coxal fracture. Methods of X-ray structure analysis used for examining tangential sections of a resected capitular of the femoral bone cartilage.
Results. A phenomenon of mineralization of cartilage due to OA amounts 72.7 % of records, in C group – 16 %. The prevalence of microcrystallisation increased in accordance with the progression of radiographic symptoms of disease. Despite women have the greater predisposition to OA, mineralization of cartilage has an even frequency for both sexes.
Conclusions. High prevalence of mineralization of articular cartilage due to OA compared with a comparable C group enables to consider the microcrystalline deposition to be an important attendant factor of the pathogenesis of this disease.

Links to authors:

M.A. Kabalyk1, A.I. Dubikov1, T.Y. Petrikeeva1, A.A. Karabtsov2, I.I. Kuzmin1, A.V. Cherepovskiy1
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)
2 Far East Geological Institute of the Russian Academy of Sciences Far East Branch (159, 100th years of Vladivostok Ave. Vladivostok 690022 Russian Federation)

1. Komendantova N.S., Kulakov Yu. V., Sinenko A.A., Lukyanov P.A. Cytokine profile in patients with rheumatoid arthritis hypercholesterolemia // Pacific Medical Journal. 2013. No. 3. P. 47–48.
2. Rheumatology: clinical recommendations / ed. by Nasonov E.L. M.: GEOTAR-Media, 2011. 752 p.
3. Antonelli M.C., Starz T.W. Assessing for risk and progression of osteoarthritis: the nurse’s role: understanding pathophysiology, epidemiology, and risk will aid nurses who are seeking to expand their role in management // Orthop. Nurs. 2012. Vol. 31, No. 2. P. 98–102.
4. Blair-Levy J.M., Watts C.E., Fiorientino N.M. [et al.]. A type I collagen defect leads to rapidly progressive osteoarthritis in a mouse model // Arthritis Rheum. 2008. Vol. 58, No.4. P. 96–106.
5. Buckwalter J.A., Martin J.A., Brown T.D. Perspectives on chondrocyte mechanobiology and osteoarthritis // Biorheology. 2006. Vol. 43. P. 603–609.
6. Eckstein F., Cotofana S., Wirth W. [et al.]. Greater rates of cartilage loss in painful knees than in pain-free knees after adjustment for radiographic disease stage: data from the osteoarthritis initiative // Arthritis Rheum. 2011. Vol. 63, No. 8. P. 57–67.
7. Fuerst M., Bertrand J., Lammers L. [et al.]. Calcification of articular cartilage in human osteoarthritis // Arthritis Rheum. 2009. Vol. 60, No. 9. P. 694–703.
8. Hayami T., Pickarski M., Zhuo Y. [et al.]. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis // Bone. 2006. Vol. 38. P. 34–43.
9. Iqbal M.N., Haidri F.R., Motiani B. Mannan A. Frequency of factors associated with knee osteoarthritis // J. Pak. Med. Assoc. 2011. Vol. 61, No. 8. P. 6–9.
10. Kirsch T., Swoboda B., Nah H. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage // Osteoarthritis Cartilage. 2000. No. 8. P. 294–302.
11. McCarthy G.M. Crystal deposition diseases: out of sight, out of mind // Curr. Opin. Rheumatol. 2005. Vol. 17. P. 312–313.
12. Mitsuyama H., Healey R.M., Terkeltaub R.A. [et al.]. Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis // Osteoarthritis Cartilage. 2007. Vol. 15, No. 5. P. 59–65.
13. Resende R.A., Fonseca S.T., Silva P.L. [et al.]. Power at hip, knee and ankle joints are compromised in women with mild and moderate knee osteoarthritis // Clin Biomech (Bristol, Avon). 2012. No. 22. P. 87–92.
14. Sadosky A., Bushmakin A., Cappelleri J.C., Lionberger D.R. Relationship between patient-reported disease severity in osteoarthritis and self-reported pain, function, and work productivity // Arthritis Res. Ther. 2010. No. 12. P. 162.
15. Yavorskyy A., Hernandez-Santana A., McCarthy G. et al. Detection of calcium phosphate crystals in the joint fluid of patients with osteoarthritis – analytical approaches and challenges // Analyst. 2008. Vol. 133, No. 3. P. 302–318.


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