Home

Eficacy of enterosorption during a chromic intoxication test

Written by Wood T.G., Krivenko L.E., Sherstneva E.P

  UDK: 615.246.2: 615.916›1:546.76 | Pages: 74–77 | Full text PDF | Open PDF 

Annotation:

Background. As the chromic intoxication accompanied by development of exo- and endotoxicoses the previously investigated is the preventive effect of pectins and ion-exchanging resins on this process. In this paper we evaluate the efficiency of the use of salt of alginic acid as an enterosorbent.
Methods. Examined the content of microelements and state of antioxidant and nervous systems of the rats exposed to an environment of the electroplating shop for the period from two weeks to three months after enterosorption with the use of sodium-calcium alginic acid (alginate) and under a proper control.
Results. At all stages of the experiment the content of chromium in the liver tissue of the control animals exceeded the norm in 4-10th times while that of the animals that took alginate it only doubled. Contents of iron, zinc and manganese coresponded to the norm while that of the rats not taking enterosorbent was reduced during the experiment. Marked the elevated level of malondialdehyde (MDA) in blood serum of the rats in the control group. At the final stage of the experiment changes of the «antiperoxide» link of the antioxidant system led to an increment in level of glutathionereductase for rats taking enterosorbent and to a decrement in level of catalase in the bood serum of the rat in the control group. The use of alginate enabled to reduce the neurotoxic effect of chromium resulted in the increased motor activity indices of the animals.
Conclusions. Sodium-calcium alginic acid (alginate) has got a high sorption activity with respect to chromium, improves microelement homeostasis, increases levels of iron, zinc and manganese, inhibits lipid peroxidation and increases activity of the antioxidant system.

Links to authors:

T.G. Wood1, L.E. Krivenko2, E.P. Sherstneva2
1 Griffith University, Gold Coast campus – Teaching Centre for Medicine and Oral Health (16 High St. Southport Qld 4215 Australia)
2 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

1. Abeuova O.A., Romashov N.R., Akhmetzhanova U.A. Kinetics of chromium in the body during its peroral entering and influence of enterosorption on it // Academician E.A. Buketov – scientist, teacher, thinker: col. thes. of intern. scientific. pract. conf. Karaganda, 2005. P. 37–44.
2. Aybasova Zh.A. Ambient air pollution with emissions from chrome industry enterprises // Medical Journal of West Kazakhstan. 2005. No. 3 (7). P. 13–19.
3. Borodin Yu.I. On functional interaction of sorbents with lymphatic structures // Problems of sorption detoxication of the body internal environment: mat. of intern. symp. Novosibirsk, 1995. P. 3–7.
4. Iztleuov M.K., Mukysheva G.D., Iztleuova G.M., Iztleuov E.M. Haematological indices of blood in the workers with chrome induced microelementoses // Actual problems of preventive Medicine, natural and social sciences and humanities of the XXI century. Aktobe, 2007. P. 40–43.
5. Iztleuov M.K., Iztleuov E.M. Diagnostic value of indices of lipid peroxidation of body biosubstrates in workers with chrome production // Innovations and information technologies in diagnostic, preventive and academic work of clinics: mat. of scientif. pract. conf. CFD RF, Tver, 2009. P. 142–143.
6. Krivenko L.E. Functional metabolic and morphological aspects of cardiorespiratory disorders in chronic bronchitis: abst. dis. doc. med. sciences. Vladivostok, 1999. 36 p.
7. Mamyrbaev A.A., Sakebaeva L.D., Satybaldieva U.A, Zasorin B.V. Indices of immune homeostasis in workers with chrome production. // Occupational medicine and industrial ecology. 2011. No. 6. P. 43–45.
8. Paliy I.G. Enterosorption role in the treatment of liver diseases // Consilium Medicum Ukraina. 2009. No. 3. P. 13–16.
9. Chernikhova E.A., Anikhovskaya I.A., Gataulin Yu.K. Enterosorption as important means of eliminating chronic endotoxin aggression // Human Physiology. 2007. No. 3. P. 135–136.
10. Yulish E.I., Krivuschev B.I. Method of enterosorption in treatment of intoxication syndrome // Child Health. 2011. No. 4 (31). P. 25–28.
11. Anderson R.A., Polansky M.M.,Bryden N.A. [et al.] Stability and absorption of chromium and absorption of chromium histidinate complexes by humans // Biological Trace Element Research. 2004. Vol. 101. P. 211–218.

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.