Eficacy of enterosorption during a chromic intoxication test

Written by Wood T.G., Krivenko L.E., Sherstneva E.P

  UDK: 615.246.2: 615.916›1:546.76 | Pages: 74–77 | Full text PDF | Open PDF 


Background. As the chromic intoxication accompanied by development of exo- and endotoxicoses the previously investigated is the preventive effect of pectins and ion-exchanging resins on this process. In this paper we evaluate the efficiency of the use of salt of alginic acid as an enterosorbent.
Methods. Examined the content of microelements and state of antioxidant and nervous systems of the rats exposed to an environment of the electroplating shop for the period from two weeks to three months after enterosorption with the use of sodium-calcium alginic acid (alginate) and under a proper control.
Results. At all stages of the experiment the content of chromium in the liver tissue of the control animals exceeded the norm in 4-10th times while that of the animals that took alginate it only doubled. Contents of iron, zinc and manganese coresponded to the norm while that of the rats not taking enterosorbent was reduced during the experiment. Marked the elevated level of malondialdehyde (MDA) in blood serum of the rats in the control group. At the final stage of the experiment changes of the «antiperoxide» link of the antioxidant system led to an increment in level of glutathionereductase for rats taking enterosorbent and to a decrement in level of catalase in the bood serum of the rat in the control group. The use of alginate enabled to reduce the neurotoxic effect of chromium resulted in the increased motor activity indices of the animals.
Conclusions. Sodium-calcium alginic acid (alginate) has got a high sorption activity with respect to chromium, improves microelement homeostasis, increases levels of iron, zinc and manganese, inhibits lipid peroxidation and increases activity of the antioxidant system.

Links to authors:

T.G. Wood1, L.E. Krivenko2, E.P. Sherstneva2
1 Griffith University, Gold Coast campus – Teaching Centre for Medicine and Oral Health (16 High St. Southport Qld 4215 Australia)
2 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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