The role of the renin-angiotensin-aldosterone system in development of microhemocirculatory malfunctions of the respiratory system of the nephrological patients

Written by Shcherban N.A., Tseluiko S.S., Landyshev Y.S.

  UDK: 626.6 – 036.2 – 06: 616.233-008.8:577.175.852 | Pages: 78–81 | Full text PDF | Open PDF 


Background. Though for the time being the role of the renin-angiotensin- aldosterone system (RAAS) in development of the sclerotic processes associated with the chronic kidney disease results in a considerable attention, the formation of fibrosis in the respiratory system still remains understudied.
Methods. The study examines 80 patients having the chronic kidney disease. With the use of radioimmunoassay determined the concentration of aldosterone and angiotensin I in serum, studied biopsies of bronchial mucosa.
Results. Detected a significant increase in the concentration of angiotensin I in all grades and of aldosterone from 4 to 5 grades of the chronic kidney disease. Subject to the severity of the illness a variety of changes in bronchi aggravated, i.e. deformation of the microvascular channels, metaplasia and atrophy of the ciliated epithelium and mucosal sclerosis until further formation of the full clinical presentation of the persisting secondary bilateral diffuse endobronchitis.
Conclusions. An excessive activation of the renin-angiotensinaldosterone system in case of the chronic kidney disease is a priority-driven factor of development of the microhemocirculatory malfunctions. The RAAS has the vasoconstrictive and fiber generating effects in the early grades while its effects associated with the mineralocorticoid aldosterone influence are revealed in the final grades.

Links to authors:

N.A. Shcherban1, S.S. Tseluiko2, Y.S. Landyshev2
1 I.P. Pavlov St. Petersburg State Medical University (6/8 Lva Tolstogo Str. St. Petersburg 197022 Russian Federation)
2 Amur State Medical Academy (95 Gorky Str. Blagoveshchensk 675013 Russian Federation)

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