Clinical features and the natural immunity state of the HIV‑infected patients having herpes meningoencephalitis

Written by Sklyar L.F., Markelova E.V., Nagornaya A.V., Sotnichenko S.A.

  UDK: 616-097-022:578:616.831.9-002:612.017 | Pages: 82–85 | Full text PDF | Open PDF 


Background. Research at systemic and local levels of a variety of clinical features of meningoencephalitis and levels of cytokines of 28 HIV-infected patients having herpes meningoencephalitis.
Methods. Verification of DNA of herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in the spinal fluid by of polymerase chain reaction. Investigated systemic and local cytokine status with the use of technique of enzyme-linked immunosorbent assay (ELISA).
Results. In 11 cases the cause of meningoencephalitis was HSV and EBV, in 17 cases – by HSV and CMV. Severity of symptoms on a point scale was higher for the second group of patients that, in addition, registered as well the higher level of pleocytosis. Subject to the level of pleocytosis also detected the severity of the clinic features of affection of the central nervous system. Detected a valid correlation between the level of interleukin-4 (IL-4) in serum and general cerebral symptoms. Detected a valid correlation at local level of the γ-interferon level and those symptoms as well.
Conclusions. The findings proves that that the pro-inflammatory potential of HIV-infected patients having affection of the central nervous system of the herpes cerebral etiology at local level exceeds the anti-inflammatory potential, and this imbalance plays an important role in the development of immunodeficiency and disease progression.

Links to authors:

L.F. Sklyar1, E.V. Markelova1, A.V. Nagornaya1, S.A. Sotnichenko2
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)
2 Far Eastern District Medical Center of the Federal Medical and Biological Agency (161 Prospect 100 years, Vladivostok 690022 Russian Federation)

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