Home

Clinical features and the natural immunity state of the HIV‑infected patients having herpes meningoencephalitis

Written by Sklyar L.F., Markelova E.V., Nagornaya A.V., Sotnichenko S.A.

  UDK: 616-097-022:578:616.831.9-002:612.017 | Pages: 82–85 | Full text PDF | Open PDF 

Annotation:

Background. Research at systemic and local levels of a variety of clinical features of meningoencephalitis and levels of cytokines of 28 HIV-infected patients having herpes meningoencephalitis.
Methods. Verification of DNA of herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in the spinal fluid by of polymerase chain reaction. Investigated systemic and local cytokine status with the use of technique of enzyme-linked immunosorbent assay (ELISA).
Results. In 11 cases the cause of meningoencephalitis was HSV and EBV, in 17 cases – by HSV and CMV. Severity of symptoms on a point scale was higher for the second group of patients that, in addition, registered as well the higher level of pleocytosis. Subject to the level of pleocytosis also detected the severity of the clinic features of affection of the central nervous system. Detected a valid correlation between the level of interleukin-4 (IL-4) in serum and general cerebral symptoms. Detected a valid correlation at local level of the γ-interferon level and those symptoms as well.
Conclusions. The findings proves that that the pro-inflammatory potential of HIV-infected patients having affection of the central nervous system of the herpes cerebral etiology at local level exceeds the anti-inflammatory potential, and this imbalance plays an important role in the development of immunodeficiency and disease progression.

Links to authors:

L.F. Sklyar1, E.V. Markelova1, A.V. Nagornaya1, S.A. Sotnichenko2
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)
2 Far Eastern District Medical Center of the Federal Medical and Biological Agency (161 Prospect 100 years, Vladivostok 690022 Russian Federation)

1. Batskalevich N.A., Verevschikov V.K., Lagereva Yu.G. Evaluation of immunity and immunotropic therapy of enteroviral meningitis // Infectious diseases. 2009. Vol. 7, No. 3. P. 30–34.
2. Isakov V.A., Arkhipova E.I., Isakov D.V. Herpesvirus infections: a guide for physicians. St. Petersburg.: SpetsLit 2006. 303 p.
3. Isakov V.A., Arkhipova E.I., Isakov D.V. Herpesvirus human infections: a guide for physicians, the 2-nd ed. revised and enlarged. St. Petersburg.: SpetsLit, 2013. 670 p.
4. Isakov V.A. Ermolenko D.K., Ermolenko E.I. [et al.]. Herpesvirus infections. Diagnosis and treatment: a guide for physicians. St. Petersburg.; V. Novgorod, 2007. 76 p.
5. Nagoev B.S., Kambachokova Z.A. Cytokine status in patients with herpesvirus infections // Infectious diseases. 2011. Vol. 9, No. 1, p. 19–22.
6. Sklyar L.F., Markelova E.V., Borovskaya N.A. [et al.]. Clinical and immunological features of herpes diseases with HIV infection // Pacific Medical Journal. 2010. No. 3. P. 62–64.
7. Trubcheninova L.P., Gudima G.O., Trefileva N.F. [et al.]. Identifying acute stage of herpesvirus infections in patients with HIV infection / / Russian allergology journal. 2011. No. 4, ed. 1. P. 384-385.
8. Prasolova M.A. Polymerase chain reaction in the diagnosis of herpesvirus human infections // Information bulletin. “Vector- Best.” 2009. No. 4. P. 2–8.
9. Yarilin A.A. Immunology. M.: GEOTAR-Media, 2010. 752 p.
10. McArthur J.C., Steiner J., Sacktor N., Nath A. Human immunodeficiency virus-associated neurocognitive disorders: mind the gap // Ann. Neurol. 2010. Vol. 67. P. 710–711.
11. Moriuchi M., Moriuchi H. Increased susceptibility to HIV-1 of peripheral blood lymphocytes in acute infection wish Epstein- Barr virus // J. Med. Virol. 2003. Vol. 71, No. 3. P. 343–346.
12. Panchenko L.A., Torianik I.I., Ppova N.G. [et al.]. Detection of markers of acute herpesvirus process, associated wish herpes simplex and Epstein-Barr herpes viruses in patients wish acute and chronic laryngitis // Annals of Mechnicov Institute. 2007. No. 3. P. 18–19.

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.