Effect of specific immunotherapy of carcinoma of uterine cervix on the state of cellular immunity

Written by Kenbaeva D.K., Manambaeva Z.A., Lazarev A.F

  UDK: 618.146-006.6-085.37:612.017 | Pages: 85–88 | Full text PDF | Open PDF 


Background. The object of research is to evaluate the efficacy of the specific immunotherapy of carcinoma of uterine cervix in a combination with the radiation therapy.
Methods. The research covers 81 patients having cervical cancer from IIB to III grades. Conducted combined radiotherapy (41 cases) and combined treatment (40 cases): radiation therapy and specific immunotherapy, i.e. the reinfusions of lymphocytes after incubation with homogenates of the tumor tissue in vitro and addition of interleukin-2. Detected indicators of cellular immunity.
Results. Significant increment of indicators due to the combined therapy registered exclusively for the absolute content of natural killer cells in IIB grade and for the relative content of killer T cells in III grade of the cancer. Normalization of the level of lymphocyte of all examined phenotypes in blood of the patients having carcinoma of uterine cervix failed to be achieved.
Conclusions. Based on the results, the conclusion is that the efficacy of the used methods of stimulation of the antitumour immunity was insufficient and it suggests developing additional ways to activate the cellular mechanisms in vivo.

Links to authors:

D.K. Kenbaeva1, Z.A. Manambaeva2, A.F. Lazarev3
1 Astana Municipal Oncological Center (7 Manas St. Astana 010000 Republic of Kazakhstan)
2 Semey State Medical University (103 Abay Kunanbaev St. Semey 007140 Republic of Kazakhstan)
3 Altai Regional Oncological Center (77, Nikitina St. 656000
Barnaul Russian Federation)

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