Increase of efficiency of surgical and chemotherapeutic methods of treatment of intertwined tumors by the extract of a Dandelion Medicinal

Written by Amosova E.N., Zueva E.P., Razina T.G., Krylova S.G., Lopatina K.A., Gur’ev A.M., Kirsanova N.V.

  UDK: 616-006.6-085.322:582.998.16-092.4 | Pages: 36–39 | Full text PDF | Open PDF 


Background. There are experimental data about the possibility of use the herb extracts in the therapy of tumors.
Methods. In experiment on mice analyzed influence of the extract of the Dandelion medicinal on metastasing of the intertwined tumors at removal of primary tumor and chemotherapeutic treatment.
Results. The dandelion extract inhibited the metastasing after the removal of the tumor and also reduced the quantity of postoperative relapses. Increase of the antiblastomic activity of cyclophosphane at animals with intertwined Ehrlich adenocarcinoma, Lewis pulmonary carcinoma, В-16 melanoma and lung cancer-67 under the influence of a dandelion extract is revealed. Allocated from this plant water-soluble polysaccharides at adding in the chemotherapy scheme also increased the efficiency of cyclophosphane at mice with Lewis pulmonary carcinoma.
Conclusions. Experimental data testify to perspective of the further study of the extract of dandelion medicinal as the substance of additional therapy of the malignant tumors.

Links to authors:

E.N. Amosova1, E.P. Zueva1, T.G. Razina1, S.G. Krylova1, K.A. Lopatina1, A.M. Gur’ev2, N.V. Kirsanova3
1 Scientific research institute of pharmacology named by E.D. Goldberg of the Siberian Branch of the Russian Academy of Medical Science (3 Lenin Ave. Tomsk 634028 Russian Federation),
2 Siberian State Medical University (2 Moscow HWY Tomsk 634050 Russian Federation),
3 National Research Tomsk State University (36 Lenin Ave. Tomsk 634050 Russian Federation),

1. Goldberg E.D., Amosova E.N., Zueva E.P., Reykhart D.V. Effect of extracts of medicinal plants for the development of metastatic process // Bulletin of Experimental Biology and Medicine. 2004. Vol. 138, No. 9. P. 324–332.
2. Goldberg E.D., Zueva E.P. Medicines made of plants in combined therapy of cancer. Tomsk: Publishing house TSU, 2000. P. 130.
3. Goldberg E.D., Razina T.G., Zueva E.P. et al. Plants of Siberia and Far East and their biologically active agents as a tumor additional remedy // Bulletin of Experimental Biology and Medicine. 2008. Appx. 2. P. 21–29.
4. Gubler E.V. Computation methods of an analysis and detection of pathological process. L.: Medicine, 1978. P. 193.
5. Zhanaeva S.Ya., Alekseenko T.V., Korolenko T.A., Zvyagintseva T.N. Antitumor and anti-metastatic activity of sulphated glycan of Fucus evanescens fucoidan of Sea of Okhtosk // Pacific Medical Journal. 2009. No. 3. P. 96–99.
6. Zueva E.P., Lopatina K.A., Razina T.G., Guriev A.M. Glycan in oncology. Tomsk: Printing manufactory, 2010. P. 108.
7. Guidelines for pre-clinical study of agents able to stop the process of metastasis and increase the effectiveness of cytostatic therapy of malignant tumors // Guidance on experimental (pre-clinical) study of new pharmacological agents / edited by R.U. Khabriev. М.: Medicine, 2005. P. 674–682.
8. Plants in combined therapy of tumors / Goldberg E.D., Razina T.G., Zueva E.P. [et al.]. М.: Publishing house RAMS, 2008. P. 232.
9. Sergeev A.V., Alieva T.A., Blanco F.F. [et al.]. Immunomodulating and antitumor activity of plant glycans // Russian Biotherapeutic Journal. 2007. Vol. 6, No. 1. P. 50.
10. Sokolov S.Ya. Phytotherapy and phytopharmacology. М.: MIA, 2000. P. 970.
11. Sofina Z.P. Syrkin A.B. Goldin A., Clein A. Experimental assessment of antitumor medicines in the USSR and the USA. М.: Medicine, 1980. P. 296.
12. Du Yu-hong, Cui Cheng-din, Li en-xin [et al.]. Zhongguo yaowu huaxue zazhi // Chin. J. Med. Chem. 2003. Vol. 13, No. 6. P. 320–323.
13. Lee H., Kim J.-S., Kim E. Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human Lung Cancer cell via PI3K-AKT-mTOR pathways // PLoS One. 2012. Vol. 7. P. 506–524.
14. Li J., Li Q.-W., Cao D.-W. [et al.]. Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum // Phytotherapy Res. 2009. Vol. 23. P. 1524–1530.
15. Wie H., Tye L., Bresnick E. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice // Cancer Res. 1990. Vol. 50, No. 3. P. 499–502.


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