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Molecular mechanisms of cellular protection in reconstructive-regenerative surgery of the main arteries

Written by Kalinin R.E., Pshennikov A.S., Suchkov I.A.

  UDK: 616.13-004.6:616.718:577.1 | Pages: 52–55 | Full text PDF | Open PDF 

Annotation:

Background. At the existing tendency to morbidity growth and increase of prevalence of risk factors of the obliterating atherosclerosis of the lower limbs the improving of conservative methods of treatment is more and more actual. As the important components of this direction are the correction of the endothelial dysfunction and stimulation of the neoangiogenesis.
Methods. 40 patients with acute and chronic ischemia of the lower limbs due to the obliterating atherosclerosis were examined. The stress-induced system indicators – nitrogen oxide, thermal shock proteins, endothelial factor of growth, Bcl-2 proteins – after reconstructive- regenerative surgeries on the main arteries and without them (control group) – were studied.
Results. The level of the thermal shock proteins and the nitrogen oxide metabolits in patients’ blood after the surgical treatment has decreased. The pilot studying of neoangiogenesis markers has shown the significant change of the endothelial growth factor comparing with the control group.
Conclusions. The revealed authentic tendencies in change of stressinducible system indicators prove their direct influence on the mechanisms of immediate and long-term adaptation to ischemic stress and reperfusive answer in the postoperative period.

Links to authors:

R.E. Kalinin, A.S. Pshennikov, I.A. Suchkov
Ryazan State Medical University named by academician I.P. Pavlov (9 Vysokovoltnaya St. Ryazan 390026 Russian Federation)


1. Kalinin R.E. Comprehensive assessment of endothelium functional condition in patients with arteriosclerosis obliterans of lower limb in different methods of surgical treatment: thesis, MD. Ryazan, 2008. P. 250.
2. Kalinin R.E., Zvyagina V.I., Pshennikov A.S. [et al.]. Photocolorimetric method of nitrogen oxide metabolites level detection in blood plasma // Astrakhan Medical. 2010. Vol. 5, No. 1. P. 188–189.
3. Kirichuk V.F., Glybochko P.V., Ponomareva A.I. Endothelium dysfunction. Saratov: Publishing house of Saratov Medical University, 2008. P. 129.
4. Clinical angiology: guidance in 2 vol. / edited by A.V. Pokrovskiy. М.: Medicine, 2004.
5. Metelskaya V.P., Chumanova N.G. Screening - a method of nitrogen oxide metabolites level detection in blood plasma // Clinical laboratory diagnostics. 2005. No. 6. P. 15–18.
6. National suggestions on case management of patients with diseases of lower limb arteries. М., 2013. P. 74.
7. Paltsev M.A., Ivanov A.A., Severin S.E. // Intercellular correlation. М.: Medicine, 2003. P. 288.
8. Pshennikov A.S. Endothelium active therapy in a combined treatment of arteriosclerosis obliterans of lower limb: thesis, PhD. Ryazan, 2012. P. 142.
9. Alcocer F., Whitley D., Salazar J. [et al.] Mutual exclusion of apoptosis and hsp70 in human vein intimal hyperplasia in vitro // J. Surg. Res. 2001. Vol. 96, No. 1. P. 75–80.
10. Currie R.W., Ross B.M., Davis T.A. Induction of the heat shock response in rats modulates heart rate, creatine kinase and protein synthesis after a subsequent hyperthermic treatment // Cardiovasc. Res. 1990. Vol. 24, No. 2. P. 87–93.
11. Fraisl P., Mazzone M., Schmidt T. [et al.] Regulation of angiogenesis by oxygen and metabolism // Dev. Cell. 2009. Vol. 16, No. 2. P. 167–179.
12. The Trans-Atlantic Inter-Society Consensus // Eur. J. Vasc. Endovasc. Surg. 2007. Vol. 33 (Suppl. 1).
13. Zhang Y., Yang H., Barnie P.A. [et al.] The expression of Toll-like receptor 8 and its relationship with VEGF and Bcl-2 in cervical cancer // Int. J. Med. Sci. 2014. Vol. 11, No. 6. P. 608–613.

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