Pharmaconutritiology of non-starch polysaccharides

Written by Khotimchenko R.Yu.

  UDK: 615.322:612.392.7:577.114 | Pages: 5–11 | Full text PDF | Open PDF 


Review of the literature devoted to the chemical structure, physicochemical properties, pharmacological activity and the nutritional value of non-starch polysaccharides, representing one of the most complex and diverse chemically groups of organic compounds. Physiological effects and mechanisms of action of nonstarch polysaccharides in animals and humans are described. The role of these compounds in the prevention of socially significant diseases, such as cardiovascular disease, obesity, diabetes, intestinal dysbiosis, and colorectal cancer. Non-starch polysaccharides are the basis for the creation of new functional foods, dietary supplements and pharmaceutical substances.

Links to authors:

R.Yu. Khotimchenko
A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences (17 Palchevskogo St. Vladivostok 690041 Russian Federation), School of Biomedicine, Far Eastern Federal University (8 Sukhanova St. Vladivostok 690950 Russian Federation)

1. Ovodov Yu.S. Modern views on pectic substances // Bioorganic chemistry. 2009. Vol. 35, No. 3. P. 293–310.
2. Khotimchenko M.Yu. Pharma nutritiology of alginates. Vladivostok: Dalnauka, 2009. 170 p.
3. Khotimchenko Yu.S. Antitumor properties of non-starch polysaccharides: fucoidans, chitosans // Marine biology. 2010. Vol. 36, No. 5. P. 319–328.
4. Khotimchenko Yu.S. Antitumor properties of non-starch polysaccharides: carrageenans, alginates, pectins // Marine biology. 2010. Vol. 36, No. 6. P. 399–409.
5. Khotimchenko Yu.S., Ermak I.M., Bednyak A.E. [et al.] Pharmacology of non-starch polysaccharides // Bulletin of FEB RAS. 2005. No. 1. P. 72–81.
6. Akin H., Tözün N. Diet, microbiota, and colorectal cancer // J. Clin. Gastroenterol. 2014. Vol. 48, Suppl. 1. P. S67–S69.
7. Alex S., Lange K., Amolo T. [et al.] Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ // Mol. Cell. Biol. 2013. Vol. 33. P. 1303–1316.
8. Anderson J.W., Randles K.M., Kendall C.W.C., Jenkins D.J.A. Carbohydrate and fiber recommendations for individuals with diabetes: A quantitative assessment and meta-analysis of the evidence // J. Am. Coll. Nutr. 2004. Vol. 23. P. 5–17.
9. Bingham S.A., Luben R., Day N.E. [et al.] Plant polysaccharides, meat and colorectal cancer // IARC Sci. Publ. 2002. Vol. 156. P. 349–352.
10. Brockman D.A., Chen X., Gallaher D.D. Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats // Nutr. Metab. (Lond.). 2012. Vol. 9, No. 1:100. doi: 10.1186/1743-7075-9-100.
11. Buttriss J.L., Stokes C.S. Dietary fiber and health: An overview // Br. Nutr. Found. Nutr. Bull. 2008. Vol. 33. P. 186–200.
12. Carlson J.J., Eisenmann J.C., Norman G.J. [et al.] Dietary fiber and nutrient density are inversely associated with the metabolic syndrome in US adolescents // J. Am. Diet. Assoc. 2011. Vol. 111. P. 1688–1695.
13. Collén P.N., Lemoine M., Daniellou R. [et al.] Enzymatic degradation of κ-carrageenan in aqueous solution // Biomacromolecules. 2009. Vol. 10. P. 1757–1767.
14. Cummings J.H., Stephen A.M. Carbohydrate terminology and classification // Eur. J. Clin. Nutr. 2007. Vol. 61. P. 5–18.
15. Eliz I., Weil E., Wilk B. Integrative medicine and role of modified citrus pectin/alginates in heavy metal chelation and detoxification – five case reports // Forsch Komplementarmed. 2007. Vol. 14. Р. 358–364.
16. Hernández R., Sacristán J., Mijangos C. Sol/gel transition of aqueous alginate solutions induced by Fe2+ cations // Macromol. Chem. Phys. 2010. Vol. 211. P. 1254–1260.
17. Howe G.R., Benito E., Castelleto R. [et al.] Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies // J. Natl. Cancer Inst. 1992. Vol. 84. P. 1887–1896.
18. Ikekawa T. Beneficial effects of edible and medicinal mushrooms in health care // Int. J. Med. Mushrooms. 2001. Vol. 3. P. 291–298.
19. Jakobsdottir G., Nilsson U., Blanco N. [et al.] Effects of soluble and insoluble fractions from bilberries, black currants, and raspberries on short-chain fatty acid formation, anthocyanin excretion, and cholesterol in rats // J. Agric. Food Chem. 2014. Vol. 62. P. 4359–4368.
20. Jones J.M. CODEX-aligned dietary fiber definitions help to bridge the “fiber gap” // Nutr. J. 2014. 13:34. doi: 10.1186/1475- 2891-13-34.
21. Kalkwarf H.J., Bell R.C., Khoury J.C. [et al.] Dietary fiber intakes and insulin requirements in pregnant women with type 1 diabetes // J. Am. Diet Assoc. 2001. Vol. 101. P. 305–310.
22. Khotimchenko M., Khozhaenko E., Kolenchenko E., Khotimchenko Y. Influence of pectin substances on strontium removal in rats // Int. J. Pharm. Pharmac. Sci. 2012. Vol. 4. P. 269–273.
23. Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. Zinc-binding activity of different pectin compounds in aqueous solutions // J. Colloid Interface Sci. 2008. Vol. 323. P. 216–222.
24. Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. [et al.] Cerium binding activity of different pectin compounds in aqueous solutions // Colloid. Surf. B. 2010. Vol. 77. P. 104–110.
25. Khotimchenko M.Y., Podkorytova E.A., Kovalev V.V. [et al.] Removal of cesium from aqueous solutions by sodium and calcium alginates // J. Environ. Sci. Technol. 2014. Vol. 7. P. 30–43.
26. Khotimchenko M., Sergushchenko I., Khotimchenko Y. The effects of low-esterified pectin on lead-induced thyroid injury in rats // Environ. Toxicol. Pharmacol. 2004. Vol. 17. P. 67–71.
27. Kim Y., Je Y. Dietary fiber intake and total mortality: a metaanalysis of prospective cohort studies // Am. J. Epidemiol. 2014. Vol. 180. P. 565–573.
28. Kranz S., Brauchla M., Slavin J.L., Miller K.B. What do we know about dietary fiber intake in children and health? The effects of fiber intake on constipation, obesity, and diabetes in children // Adv. Nutr. 2012. Vol. 3. P. 47–53.
29. Kumar M., Nagpal R., Verma V. [et al.] Probiotic metabolites as epigenetic targets in the prevention of colon cancer // Nutr. Rev. 2013. Vol. 71. P. 23–34.
30. Kumar V., Sinha A.K., Makkar H.P. [et al.] Dietary roles of nonstarch polysaccharides in human nutrition: a review // Crit. Rev. Food Sci. Nutr. 2012. Vol. 52. P. 899-935.
31. Lazaridou, A., Biliaderis, C.G., Izydorczyk, M.S. Molecular size effects on rheological properties of oat β-glucans in solutions and gels // Food Hydrocolloid. 2003. Vol. 17. P. 693–712.
32. Levitskaia T.G., Creim J.A., Curry T.L. [et al.] Biomaterials for the decorporation of 85Sr in the rat // Health Phys. 2010. Vol. 99. P. 393–400.
33. Mansour A., Hosseini S., Larijani B. [et al.] Nutrients related to GLP1 secretory responses // Nutrition. 2013. Vol. 29. P. 813–820.
34. Mehta N., Ahlawat S.S., Sharma D.P., Dabur R.S. Novel trends in development of dietary fiber rich meat products-a critical review // J. Food Sci. Technol. 2015. Vol. 52. P. 633–647.
35. Meyer D. Health benefits of prebiotic fibers // Adv. Food Nutr. Res. 2015. Vol. 74. P. 47–91.
36. Nesterenko V.B., Nesterenko A.V. 13. Decorporation of Chernobyl radionuclides // Ann. N.Y. Acad. Sci. 2009. No. 1181. P. 303–310.
37. Prajapati V.D., Jani G.K., Moradiya N.G. [et al.] Galactomannan: a versatile biodegradable seed polysaccharide // Int. J. Biol. Macromol. 2013. Vol. 60. P. 83–92.
38. Qiao Z., Koizumi Y., Zhang M. [et al.] Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells // Biosci. Biotechnol. Biochem. 2012. Vol. 76. P. 1877–1883.
39. Rodriguez R., Jimenez A., Bolanos J.F. [et al.] Dietary fiber from vegetable products as source of functional ingredients // Trends Food Sci. Technol. 2006. Vol. 17. P. 3–15.
40. Schulze M.B., Liu S. Rimm E.B. [et al.] Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women // Am. J. Clin. Nutr. 2004. Vol. 80. P. 348–356.
41. Schwartz B., Hadar Y. Possible mechanisms of action of mushroom- derived glucans on inflammatory bowel disease and associated cancer // Ann. Transl. Med. 2014. doi: 10.3978/j. issn.2305-5839.2014.01.03.
42. Scott K.P., Duncan S.H., Flint H.J. Dietary fiber and the gut microbiota // Nutr. Bull. 2008. Vol. 33. P. 201–211.
43. Song M., Garrett W.S., Chan A.T. Nutrients, foods, and colorectal cancer prevention // Gastroenterology. 2015. pii: S0016- 5085(15)00011-6. doi: 0.1053/j.gastro.2014.12.035.
44. Thiengwilboonwong S., Chongsuwat R., Temcharoen P. [et al.] Efficacy of dietary modification following the National Cholesterol Education Program (NCEP) recommendation on lipid profiles among hyperlipidemia subjects // J. Med. Assoc. Thai. 2013. Vol. 96. P. 1257–1267.
45. Tsuda T. Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1secretion // Mol. Nutr. Food Res. 2015. doi: 10.1002/mnfr.201400871.
46. Wang Q., Ellis P.R. Oat β-glucan: physico-chemical characteristics in relation to its blood-glucose and cholesterol-lowering properties // Br. J. Nutr. 2014. Vol. 112. P. S4–S13.
47. Wong S.M., Wong K.K., Chiu L.C.M., Cheung P.C.K. Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction // Carbohydr. Polym. 2007. Vol. 68. P. 206–217.
48. Younes I., Rinaudo M. Chitin and chitosan preparation from marine sources. Structure, properties and applications // Mar. Drugs. 2015. Vol. 13. P. 1133–1174.
49. Zhang M., Chiu L.C., Cheung P.C., Ooi V.E. Growth inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: Cell-cycle arrest and apoptosis induction // Oncol. Rep. 2006. Vol. 15. P. 637–643.
50. Zheng X., Li L., Wang X. Molecular characterization of arabinoxylans from hull-less barley milling fractionsles // Molecules. 2011. Vol. 16. P. 2743–2753.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.