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Mutagenic characteristics research of α(1,2)-l-ramno-α(1,4)- d‑galactopiranoziluronan Acorus calamus L.

Written by Neupokoeva О.V., Lopatina K.А., Voronova О.L., Safonova Е.А., Zueva Е.P., Churin А.А.

  UDK: 615.322:581.154:577.114:615.277.3 | Pages: 22–23 | Full text PDF | Open PDF 

Annotation:

Background. Toxic testing of new pharmacological substances is an obligatory part of preclinical drug development. Nowadays RIPRM named E.D. Goldberg study a medicine based α(1,2)-L-рамно- α(1,4)-D-галактопиранозилуронана from rhizomes Acorus calamus L. Methods. Somatic mosaicism were tested in Drosophila melanogaster. Mutant bristles of heterozygous female of first generation phenotype singed were counted as well spots and bristles on the bodies of phenotype yellow after breeding them in the environment with adding of the studied medicine, concentration 4 and 6.25 %. Results. Authentic differences were not detected in experimental groups in females compared with control groups. Conclusions. A(1,2)-L-ramno-α(1,4)-D-galactopiranoziluronan Acorus calamus L. does not display mutagenic characteristics.

Links to authors:

О.V. Neupokoeva1, K.А. Lopatina1, 2, О.L. Voronova1, Е.А. Safonova1, Е.P. Zueva1, А.А. Churin1
1 Research Institute of Pharmacology and Regenerative Medicine named E.D. Goldberg (3 Lenina Ave. Tomsk 634028 Russian Federation),
2 National Research Tomsk State University (36 Lenina Ave. Tomsk 634050 Russian Federation)


1. Gurev A.M., Belousov M.V., Akhmedzhanova R.R. [et al.] The study of mutagenic properties of water-soluble polysaccharides of Calamus // Experimental and Clinical Pharmacology. 2010. Vol. 73, No. 8. P. 43–45.
2. Zueva E.P., Lopatina K.A., Razina T.G., Gurev A.M. Polysaccharides in oncology. Tomsk: Printing manufactory, 2010. 108 p.
3. Lakin G.F. Biometry. М.: Higher School, 1980. 293 p.
4. Guidelines on the assessment of mutagenic properties of drugs // Guidelines for conducting pre-clinical trials of medicinal products. Pert I. М., 2013. P. 94–114.
5. Guidelines on the use of somatic mutagenesis in D. melanogaster as a test system for rapid determination of carcinogens. М.: MOH USSR, 1982. 13 p.
6. Safonova E.A., Gurev A.M., Razina T.G. [et al.] Increased effectiveness of chemotherapy using pharmacologically active fractions isolated from the complex polysaccharide of Calamus (Acorus calamus L.) // Russian Biotherapeutic Journal. 2012. Vol. 11, No. 4. P. 55–58.
7. Safonova E.A., Lopatina K.A., Vetoshkina T.V. [et al.] Correction of hepatotoxicity of cyclophosphamide water-soluble polysaccharides of foalfoot and Calamus // Bulletin of Siberian Medicine. 2011. No. 1. P. 70–75.

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