The neuronal markers contents study in some infectious diseases

Written by Dyuizen I.V., Ivanis V.А., Mihailov А.С., Menchinskaya Е.С., Manzhulo I.V., Ogurtsova О.С.

  UDK: 616.831-02:616.9-074/076 | Pages: 27–30 | Full text PDF | Open PDF 


Background. Serum levels of such proteins as the S100, glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) give an idea of the severity, depth and extent of the lesion of brain structures. Methods. In the serum of 20 patients with hemorrhagic fever with renal syndrome and chronic hepatitis C virus protein concentration was determined S100, GFAP and NSE. Results. The level of S100 in serum in hemorrhagic fever with renal syndrome has been raised 13 times; the concentration of GFAP did not differ from the control values, the content of NSE in 11 cases was increased by 5 times. S100 and GFAP levels in the serum of patients with chronic hepatitis C were close to normal values; the content of NSE in 11 patients was increased by 3 times. Conclusions. The presence of violations of the permeability of the blood-brain barrier, and neuropathology, possibly vascular and autoimmune origin that involves the cells of the neuroendocrine system in the pathogenesis of encephalopathy in hemorrhagic fever with renal syndrome and chronic hepatitis C virus.

Links to authors:

I.V. Dyuizen, V.А. Ivanis, А.С. Mihailov, Е.С. Menchinskaya, I.V. Manzhulo, О.С. Ogurtsova
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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