Some aspects of medical care for children with food intolerance

Written by Vasilyeva T.G., Shumatova T.A., Nee A., Grigoryan L.A., Voronin S.V.

  UDK: 616.33/34-008.1-053.2-074 | Pages: 36–39 | Full text PDF | Open PDF 


Background. Food intolerance (FI) is a common, complex, multidisciplinary problem in pediatrics requiring additional search of criteria for the diagnosis, and study of risk factors. Methods. The adverse factors of ontogeny were studied; the coefficient of relative and attributable risk of formation of FI in 50 children aged 10 to 15 years was calculated. The frequency of polymorphisms CC, CT , TT MCM6 gene in 10 children with lactase deficiency was studied. Immunoreactive trypsin in the blood of 24305 newborns was studied. Results. Most of the studied factors were assigned to groups with low and increased susceptibility to the development of FI (88.6 %). The high level of attributable risk indicators had only 5 indexes (11.4 %). Preliminary data on the frequency of genotypes MCM6 are CC and TT (30 %) and CT (40 %). The diagnostic and prognostic value of determination of calprotectin in feces during gastrointestinal manifestations of food allergy was proved. The high frequency of latent celiac disease dictates the need to intensify research HLA-DQ2 and DQ8. High levels of immunoreactive trypsin was detected in 1.37 % of newborns, positive retest at 0.18 %. The incidence of cystic fibrosis was 1 patient at 4861 newborns. Conclusions. In the process of verification of food intolerance it is important to use all available means, from assessing the relative and attributable risk of formation of this pathology to the confirmation of the genetic separate clinical entities. risk factors of food intolerance, genetic markers, lactase deficiency, cystic fibrosis

Links to authors:

T.G. Vasilyeva1, 2, T.A. Shumatova1, A. Nee1, L.A. Grigoryan1, S.V. Voronin2
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 Regional Clinical Center of specialized medical care (30/27, Uborevicha Str. Vladivostok 690091 Russian Federation)

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