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Matrix metalloproteinases 14 and 17 as factors of revascularization in adenomyosis

Written by Tkachyova Е.V., Gorelik М.Z., Dyuizen I.V.

  UDK: 618.145-02:612.015.13 | Pages: 69–73 | Full text PDF | Open PDF 

Annotation:

Background. The localization of matrix metalloproteinases (MMPs) 14 and 17 was studied in eutopic en-dometrial tissue of women with internal endometriosis. Methods. The study included 20 women of childbearing age suffering from dysfunctional uterine bleeding and infertility. The control group consisted of patients with no signs of endometriosis, who had a history of pregnancy. The endometrial biopsy was detected the presence and location of MMP14 and MMR17 by immunohistochemistry. Results. All women with endometriosis diagnosed glandular endometrial hyperplasia and tissue changes observed selective localization and activity of MMP14 and MMR17. In the endometrial stroma adenomy-osis was a growing activity of MMP14 in the wall of blood vessels and MMP14 expressed MMR17, and in the cells of uterine glands appearing not peculiar stage of the cycle MMR17. Conclusions. Eutopic endometrial tissue of women with adenomyosis are characterized by changing the profile of activity of some MMPs. Together, these changes may disrupt the support and signaling proper-ties of the fabric, creating favorable conditions for endometrioid heterotopia.

Links to authors:

Е.V. Tkachyova1, М.Z. Gorelik2, I.V. Dyuizen1
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 Primorsky Regional Patho-anatomical Department (4 Ostryakova Ave. Vladivostok 690002 Russian Federation)


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