Matrix metalloproteinases 14 and 17 as factors of revascularization in adenomyosis

Written by Tkachyova Е.V., Gorelik М.Z., Dyuizen I.V.

  UDK: 618.145-02:612.015.13 | Pages: 69–73 | Full text PDF | Open PDF 


Background. The localization of matrix metalloproteinases (MMPs) 14 and 17 was studied in eutopic en-dometrial tissue of women with internal endometriosis. Methods. The study included 20 women of childbearing age suffering from dysfunctional uterine bleeding and infertility. The control group consisted of patients with no signs of endometriosis, who had a history of pregnancy. The endometrial biopsy was detected the presence and location of MMP14 and MMR17 by immunohistochemistry. Results. All women with endometriosis diagnosed glandular endometrial hyperplasia and tissue changes observed selective localization and activity of MMP14 and MMR17. In the endometrial stroma adenomy-osis was a growing activity of MMP14 in the wall of blood vessels and MMP14 expressed MMR17, and in the cells of uterine glands appearing not peculiar stage of the cycle MMR17. Conclusions. Eutopic endometrial tissue of women with adenomyosis are characterized by changing the profile of activity of some MMPs. Together, these changes may disrupt the support and signaling proper-ties of the fabric, creating favorable conditions for endometrioid heterotopia.

Links to authors:

Е.V. Tkachyova1, М.Z. Gorelik2, I.V. Dyuizen1
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 Primorsky Regional Patho-anatomical Department (4 Ostryakova Ave. Vladivostok 690002 Russian Federation)

1. Kogan E.A., Unanyan A.L., Demura T.A. [et al.] Clinical and morphological parallels and molecular aspects of adenomyosis // Archives of Pathology. 2008. No. 5. P. 8–12.
2. Collette T., Bellehumeur C., Kats R. [et al.] Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosisand for involvement of matrix metalloproteinase-9 // Human Reproduction. 2004. Vol. 19, No. 6. Р. 1257–1264.
3. Coyle R.C., Latimer A., Jessen J.R. Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: Evidence for an interaction with non-canonical Wnt signaling // Experimental cell research. 2008. No. 314. Р. 2150–2162.
4. Curry J.T.E., Osteen K.G. Cyclic changes in the matrix metalloproteinase system in the ovary and uterus // Biology of Reproduction. 2001. No. 64. Р. 1285–1296.
5. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression // Nat Rev Cancer. 2002. No. 2. Р. 161–174.
6. English William R., Xose S., Jose M.P. [et al.] Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor- a convertase activity but does not activate pro-MMP2 // The Journal of Biological Chemistry. 2000. Vol. 275, No. 19. Р. 14046–14055.
7. Freitas S., Meduri G., Le Nestour E. Expression of metalloproteinases and their inhibitors in blood vessels in human endometrium // Biology of Reproduction. 1999. No. 61. Р. 1070–1082.
8. Gilabert-Estelle J., Estelle A., Gilabert J. Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis // Human Reproduction. 2003. Vol. 18, No. 7. Р. 1516–1522.
9. Giudice L.C, Tazuke S.I., Swiersz L. Status of current research on endometriosis // Journal Reprod Me. 1998. No. 43. Р. 252–262.
10. Holmbeck K., Bianco P., Yamada S. [et al.] MT1-MMP: a tethered collagenase // Journal of Cellular Physiology. 2004. No. 200. Р. 11–19.
11. Laudanski P., Szamatowicz J., Ramel P. Matrix metalloproteinase- 13 and membrane type-1 matrix metalloproteinase in peritoneal fluid of women with endometriosis // Gynecological Endocrinology. 2005. Vol. 21, No. 2. Р. 106–110.
12. Machado D.E., Berardo P.T., Palmero C.Y. Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases // Journal of Experimental & Clinical Cancer Research. 2010. Vol. 29, No. 4. Р. 1–9.
13. Marion W., Kramer J., Schem C. [et al.] Differential expression of MMP-2, MMP-9 and PCNA in endometriosis and endometrial carcinoma // European Journal of Obstetrics & Gynecology and Reproductive Biology. 2012. No. 160. Р. 74–78.
14. Roopali R., Yang J., Moses M.A. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer// Journal Oncology. 2009. Vol. 27, No. 31. Р. 5287–5297.
15. Sounni N.E., Devy L., Hajitou A. [et al.] MT1- MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression // FASEB Journal. 2002. No. 16. Р. 555–564.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.