Home

Hepatoprotective effect of the composition of natural antioxidant and enterosorbent

Written by Plaksen N.V., Ustinova L.V., Stepanov S.V., Trofimova А.А., Gorovaya N.Y.

  UDK: 616.36-002:615.9-085.244/.246.2:615.014.425 | Pages: 73–75 | Full text PDF | Open PDF 

Annotation:

Background. To reduce the endogenous intoxication syndrome at toxic liver disease in medical practice chelators, including enterosjell, are used. To enhance the effect of enterosjell it is possible to use natural antioxidants. Mehtods. In the experiment on mongrel male rats toxic hepatitis was simulated. The biochemical parameters of blood plasma and liver were studied in the background enteral injection of enterosjell, of syrup from the juice of Kamchatka bilberry and their composition: enterosjell and syrup from the juice of Kamchatka bilberry. Results. The experimental results show a decrease in the intensity of free radical oxidation and biochemical indices normalization when intake of the antioxidant composition of enterosorbent operating more efficiently than its components separately. Conclusions. The syrup from the juice of Kamchatka bilberry has such an effect due to the presence of the biologically active substances in the Vaccinium praestans. The results are an experimental justification of the use of enterosorbent with biologically active food supplements as a preventive or therapeutic agent for a subsidiary toxic hepatitis.

Links to authors:

N.V. Plaksen, L.V. Ustinova, S.V. Stepanov, А.А. Trofimova, N.Y. Gorovaya
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)


1. Ananich I.V., Derkho M.A. Biochemical features of rat blood // Vet clinic. 2008. No. 10. P. 18–19.
2. Vengerovskiy A.I., Markova I.V., Saratikov A.S. Preclinical study of hepatoprotective medicines // Bulletin of Pharmacological Committee. 1999. No. 2. P. 9–12.
3. Kurkin V.A., Kulagin O.L., Dodonov N.S. [et al.] Antioxidant activity of some tonic and hepatoprotective herbal drugs containing flavonoids and phenylpropanoids // Plant Resources. 2008. Vol. 44, No. 1. P. 122–130.
4. Nikolaev V.G., Mikhaylovskiy S.V., Nikolaeva V.V. [et al.] Enterosorption: State-of-the-art and Future Prospects // Bulletin of Biological and Medical Issues. 2007. V. 4. P. 7–17.
5. Plaksen N.V., Stepanov S.V., Ustinova L.V. Hepatoprotective effect of the syrup from the fruit of Vaccinium excellent // Pacific Medical Journal. 2014. No. 2. P. 59–61.
6. Syrups. General specifications: a collection of recipes on syrups according to GOST 28499–90. М.: AgroNIITEIMMP. 132 p.
7. Khotimchenko Yu.S. Enterosorbents: textbook. Vladivostok: Medicine FE. 2006. 120 p.
8. Buege J.L., Aust S.D. Microsomal lipid peroxidation // Methods in Enxymology. Academic Press. 1978. P. 302–310.

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.