Home

Middle East respiratory syndrome: when will smouldering focus outbreak?

Written by Shchelkanov M.Yu., Ananiev V.Yu., Kuznetsov V.V., Shumatov V.B.

  UDK: 616.98:578.834-036.2(5-012) | Pages: 94–98 | Full text PDF | Open PDF 

Annotation:

Modern data (from 21.03.2012 upto 17.05.2015) about Middle East respiratory syndrome coronavirus (MERS-CoV) are discussed in the review: events, which have led to the discovery of the virus, its modern taxonomic status (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, subgenus C), virion morphology, genome structure, scheme of genome replication and gene expression, model of virus circulation in the Middle Eastern natural foci, clinical features of the disease and epidemical dynamics. Increased epidemical activity of MERS-CoV is suggested to be linked with future emergence of large epidemic outbreak beyond the base areal.

Links to authors:

M.Yu. Shchelkanov1, 2, V.Yu. Ananiev1, 2, V.V. Kuznetsov1, V.B. Shumatov1
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 Hygiene and Epidemiology Center in Primorsky Krai (36 Utkinskaya Str. Vladivostok 690091 Russian Federation)


1. Alkhovskiy S.V., Lvov D.K., Schelkanov M.Yu. [et al.] Taxonomy of virus Issyk-Kul (Issyk-Kul virus, ISKV; Bunyaviridae, Nairovirus), pathogen of Issyk-Kul fever, isolated from bats (Vespertilionidae) and ticks Argas (Carios) vespertilionis (Latrelle, 1796) // Issues of Virology. 2013. Vol. 58, No. 5. P. 11–15.
2. Anischenko M., Schelkanov M.Yu., Alekseev V.V. [et al.] Molecular markers of pathogenicity of virus of West Nile // Issues of Virology. 2010. Vol. 55, No. 1. P. 4–10.
3. Lvov D.K., Alkhovskiy S.V., Schelkanov M.Yu. [et al.] Taxonomy of virus Sokuluk (SOKV Sokuluk virus) (Flaviviridae, Flavivirus, antigen complex of Entebbe bats), isolated in Kirghizia from common pipistrelle bats (Vespertilio pipistrellus Schreber, 1774), ear ticks (Argasidae Koch, 1844) and birds // Issues of Virology. 2014. No. 1. P. 30–34.
4. Lvov D.K., Alkhovskiy S.V., Schelkanov M.Yu. [et al.] The usage of modern molecular genetic techniques for biosafety // Bulletin of RVMA. 2014. No. 3. P. 115–127.
5. Lvov D.K., Schelkanov M.Yu. Filoviruses (Filoviridae) // Guideline on virology. Viruses and viral infections of humans and animals. М.: MIA, 2013. P. 202–205.
6. Lvov D.K., Schelkanov M.Yu. Order Nidovirales // Guideline on virology. Viruses and viral infections of humans and animals. М.: MIA, 2013. P. 205–208.
7. Lvov D.K., Schelkanov M.Yu. Arteriviruses (Arteriviridae) // Guideline on virology. Viruses and viral infections of humans and animals. М.: MIA, 2013. P. 208–211.
8. Lvov D.K., Schelkanov M.Yu. Coronaviruses (Coronaviridae) // Guideline on virology. Viruses and viral infections of humans and animals. М.: МIA, 2013. P. 211–218.
9. Lvov D.K., Schelkanov M.Yu. Roniviruses (Roniviridae) // Guideline on virology. Viruses and viral infections of humans and animals. – М.: МBF, 2013. P. 218–220.
10. Lvov D.N., Schelkanov M.Yu., Dzharkenov A.F. [et al.] Population interaction of West Nile Virus (Flaviviridae, Flavivirus) with arthropod vectors, vertebrate animals, people in the middle and lower zones of the Volga delta, 2001–2006 // Issues of Virology. 2009. Vol. 54, No. 2. P. 36–43.
11. Schelkanov M.Yu. Evolution of the highly virulent influenza A virus (H5N1) in Northern Eurasia ecosystem: thesis of MD. М., 2010. 488 p.
12. Schelkanov M.Yu., Gromashevskiy V.L., Lvov D.K. The role of ecological and virological zoning in predicting the impact of climate change on habitats of arboviruses // Bulletin RAMS. 2006. No. 2. P. 22–24.
13. Schelkanov M.Yu., Kolobukhina L.V., Lvov D.K. Human coronaviruses (Nidovirales, Coronaviridae): the increased level of danger of the epidemic // Therapist. 2013. No. 10. P. 49–54.
14. Schelkanov M.Yu., Lvov D.K. A new subtype of influenza A virus from bats and the new challenges of ecological and virological monitoring // Issues of Virology. 2012. Appx. 1. P. 159–168.
15. Schelkanov M.Yu., Magassouba N.F., Boiro M.Y., Maleev V.V. The causes of the epidemic of Ebola in West Africa // Therapist. 2014. No. 11. P. 30–37.
16. Schelkanov M.Yu., Zoumanigui N., Boiro M.Ye., Maleev V.V. The five ‘myths’ about the Ebola: where the fiction ends? // Russian Medical Journal. 2015. No. 2. P. 58–65.
17. Abdel-Moneim A.S. Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations // Arch. Virol. 2014. Vol. 159, No. 7. P. 1575–1584.
18. Azhar E.I., Hashem A.M., El-Kafrawy S.A. [et al.] Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient // MBio. 2014. Vol. 5, No. 4. P. e01450–14.
19. Bermingham A., Chand M.A., Brown C.S. [et al.] Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012 // Euro Surveill. 2012. Vol. 17, No. 40. P. 1–9.
20. Bondre V.P., Jadi R.S., Mishra A.C. [et al.] West Nile virus isolates from India: evidence for a distinct genetic lineage // J. Gen. Virol. 2007. Vol. 88, Pt 3. P. 875–884.
21. Brinton M.A. The molecular biology of West Nile Virus: a new invader of the western hemisphere // Ann. Rev. Microbiol. 2002. Vol. 56. P. 371–402.
22. Cauchemez S., Van Kerkhove M.D., Riley S. [et al.] Transmission scenarios for Middle East respiratory syndrome coronavirus (MERS-CoV) and how to tell them apart // Euro surveillance. 2013. Vol. 18, No. 24. P. 1–7.
23. CDC. Novel Coronavirus. Update, case definitions, and guidance 29 May 2013 // URL: www.cdc.gov/coronavirus/ncv/case-def. html (дата обращения 15.05.2015).
24. Cotton M., Lam T.T., Watson S.J. [et al.] Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus // Emerg. Infect. Dis. 2013. Vol. 19, No. 5. P. 736–742.
25. De Groot R.G., Baker S.C., Baric R.S. [et al.] Middle East respiratory syndrome coronavirus (MERS-CoV); announcement of the coronavirus study group // J. Virol. 2013. Vol. 87, No. 14. P. 7790–7792.
26. Gortazar C., Segales J. Middle East respiratory syndrome (MERS) coronavirus: a new challenge for veterinarians? // Vet. Path. 2013. Vol. 50, No. 6. P. 954–955.
27. Hemida M.G., Perera R.A., Wang P. [et al.] Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013 // Euro Surveill. 2013. Vol. 18, No. 50. P. 20659.
28. Lim P.L., Lee T.H., Rowe E.K. Middle East Respiratory Syndrome coronavirus (MERS-CoV): Update 2013 // Curr. Infect. Dis. Rep. 2013. Vol. 15, No. 4. P. 295–298.
29. Lvov D.K., Shchelkanov M.Yu., Prilipov A.G. [et al.] Evolution of HPAI H5N1 virus in Natural ecosystems of Northern Eurasia (2005–2008) // Avian Dis. 2010. Vol. 54. P. 483–495.
30. McMullen A.R., May F.J., Li L., Guzman H. [et al.] Evolution of new genotype of West Nile virus in North America // Emerg. Infect. Dis. 2011. Vol. 17, No. 5. P. 785–793.
31. Memish Z.A., Mishra N., Olival K.J. [et al.] Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia // Emerg. Infect. Dis. 2013. Vol. 19, No. 11. P. 1819–1823.
32. Muller M.A., Raj V.S., Muth D. [et al.] Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines // mBio. 2012. Vol. 3, No. 6. P. e00515–12.
33. Pebody R.G., Chand M.A., Thomas H.L. [et al.] The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012 // Euro Surveill. 2012. Vol. 17, No. 40. P. 20292.
34. Reusken C.B., Ababneh M., Raj V.S. [et al.] Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013 // Euro Surveill. 2013. Vol. 18, No. 50. P. 20662.
35. Reusken C.B., Haagmans B.L., Muller M.A, [et al.] Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study // Lancet Infect. Dis. 2013. Vol. 13, No. 10. P. 859–866.
36. Sutton T.C., Subbarao K. Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus // Virology. 2015. Vol. 479. P. 247–258.
37. Wernery U., Corman V.M., Wong E.Y. [et al.] Acute middle East respiratory syndrome coronavirus infection in livestock Dromedaries, Dubai, 2014 // Emerg. Infect. Dis. 2015. Vol. 21, No. 6. P. 1019–1022.
38. WHO. Summary table of SARS cases by country, 1 November 2002 – 7 August 2003 // URL: www.who.int/csr/sars/country/ 2003_08_15/en/index.html (дата обращения 15.05.2015).
39. WHO. Revised interim case definition for reporting to WHO Middle East respiratory syndrome coronavirus (MERS-CoV). Interim case definition as of 3 July 2013 // URL: http://www.who. int/csr/disease/coronavirus_infections/case_definition/en/index. html ( дата обращения 15.05.2015).
40. Zaki A.M., van Boheemen S., Bestebroer T.M. [et al.] Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia // N. Engl. J. Med. 2012. Vol. 367. P. 1814–1820.

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.