Oncolytic activity of Newcastle disease virus

Written by Yurchenko K.S., Gubanova N.V., Shestopalova L.V., Shchelkanov M.Yu., Shestopalov A.M.

  UDK: 616–006–085.277.3:578.831.1 | Pages: 14–18 | Full text PDF | Open PDF 

Modern data about mechanisms of selective oncolytic activity of Newcastle disease virus (APMV 1 – avian paramyxovirus 1) (Mononegavirales, Paramyxoviridae, Paramyxovirinae, Avulavirus) are analyzed, application of this virus for oncolytic virotherapy – new direction of clinical investigations – is substantiated, thesis about the necessity of intensification of studies of Russian strain oncolytic properties is formulated.

Links to authors:
K.S. Yurchenko1, N.V. Gubanova2, 3, L.V. Shestopalova3, M.Yu. Shchelkanov4, A.M. Shestopalov1
1 Scientific-Research Institute of Experimental and Clinical Medicine(2 Timakov St. Novosibirsk 630117 Russian Federation),
2 Institute of Cytology and Genetics (10 Prospekt Lavrentieva, Novosibirsk 630090 Russian Federation),
3 Novosibirsk State University (2 Pirogov St. Novosibirsk 630090 Russian Federation),
4 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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