Additional immunological criterion of early diagnosis of primary openangle glaucoma

Written by Rukina D.A., Hohlova A.S., Ivanis V.A., Shulgina N.A., Markelova E.V.

  UDK: 617.7–007.681–021.3–078.73:612.017.1 | Pages: 29–31 | Full text PDF | Open PDF 


Background. System (blood) and local (lacrimal fluid) products of interleikin- 17 (IL-17) were studied in patients with primary openangle glaucoma (POAG) and in patients at risk of developing glaucoma.
Methods. 80 patients with POAG and 35 patients at risk group (myopia, hypertensive disease I–II stage, diabetes of II-type) were examined, control group – 30 apparently healthy volunteers.
Results. System and local hyperproduction of IL-17 at POAG was detected, which is an evidence of cytokine participation in chronic immune inflammation.
Conclusions. In patients with hypertension the production level of IL-17 does not relate to the risk development of glaucoma. At diabetes of II type IL-17, in lacrimal fluid more than 1,44 pg/ml, demonstrated a high risk development of POAG. In patients with myopic refraction with and without glaucoma there were registered the most significant increase of IL-17 concentration. Local level of IL-17 more than 3,22 pg/ml in patients with myopia may be considered as additional early marker of POAG diagnosis. Keywords: interleikin-17, myopia, diabetes, ROC-analyses.

Links to authors:

D.A. Rukina1, A.S. Hohlova2, V.A. Ivanis2, N.A. Shulgina2, E.V. Markelova2
1 Regional Clinical Hospital No. 2 (55 Russkaya St. Vladivostok 690105 Russian Federation),
2 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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