The optical density of the cornea at the stage of secondary endothelium-epithelium dystrophy

Written by Luzianina V.V.

  UDK: 616.713–002.43–073 | Pages: 39–41 | Full text PDF | Open PDF 


Background. Research objective is an informative value of selective optical density of the cornea (ODC) according to Scheimpflug-densitometry at stages of the endothelial-epithelial dystrophy (EED).
Methods. 30 patients (30 eyes) with unilateral secondary EED were examined, which developed after 3–6 months after implantation of intraocular lenses. We conducted traditional ophthalmologic investigation, measuring the optical density of the corneal and pachymetry with the analyzer WaveLight Oculyzer (USA), and also a determination the density of endothelial cells with the microscope TomeyEM-300 (Germany). Based Scheimpflug densitometry based selective indices (grafts) ODC were evaluated: endothelium-descemetostromal (100 micron internal), stromal and epithelial (100 micron outside).
Results. Increase ODC was indicated in all patients at all stages of disease progress. Earlier increase ODC was defined compared with the thickness of the cornea according to pachymetry at the stromal stage. When densitometry Sheympflyug images maximum ODC recorded in a 100 micron outer epithelial grafts at each stage of the progression of EED.
Conclusions. Increase of total optic density of the cornea index in 2 times and selective optic density of internal 100 micron graft of the cornea index in 1.5 times are the diagnostic criteria of the decompensation of barrier and the pumping function of the endothelium, and are topographometric criteria of subclinical development of chronic corneal edema.

Links to authors:

V.V. Luzianina
Primorsky center of eye microsurgery (100e Borisenko St. Vladivostok 690088 Russian Federation)

1. Volkov V.V., Dronov M.M. New in the treatment of deep corneal dystrophy // International Conference on keratoplasty and keratoprosthesis: abstracts. Odessa, 1978. P. 90–92.
2. Gorgiladze T.U., Ivanovskaya E.V., Gorgiladze L.T. Reasons, mechanism of development, clinical and anatomical classification of bullous keratopathy. // Ophthalmological Journal. 1992. No. 3. P. 129–133.
3. Drozdov I.V. Surgical treatment of epithelial and endothelial corneal dystrophy by automated lamellar keratoplasty, and the use of ultra-thin transplants: thesis abstract, PhD. М., 2013. 22 p.
4. Malyugin B.E., Moroz Z.I., Drozdov I.V. [et al.]. Endothelial keratoplasty (literature review) // Ophthalmosurgery. 2013. No. 1. P. 66–72.
5. Nerpina M.E., Pozharitskiy M.D. Comparative characteristics of pachymetry methods of anterior segment // Pacific Medical Journal. 2014. No. 4. P. 76–77.
6. Oganesyan O.G. Surgical rehabilitation system of patients with corneal endothelial disorders: thesis abstract, MD. М., 2011. 36 p.
7. O.G. Oganesyan. Endokeratoplasty as an alternative to the through rekeratoplasty // Ophthalmology. 2009, Vol. 6, No. 2. P. 15–21.
8. Puzikova O.A. Research on efficiency of corneal cross-linking use for the treatment of endothelial and epithelial corneal dystrophy: thesis abstract, PhD. М., 2013. 22 p.
9. Smetanina M.A. Microinvasive descemetoplasty in the treatment of endothelial corneal dystrophy: thesis abstract, PhD. М., 2011. 24 p.
10. Narayanan R., Gaster R.N., Kenney M.C. Pseudophakie corneal edema: a review of mechanisms and treatments // Cornea. 2006. Vol. 25, No. 9. P. 993–1004.
11. Payrau P. Treatment des keratopathies ademateuses chroniques // Ann. Oculist. 1973. Vol. 206. P. 749–752.
12. Website of Eye Bank Association of America. URL: http://www.restoresight. org/wp-content/uploads/2013/04/2012_Statistical_Report_ FINAL-reduced-size-4-10.pdf.-2013 (date of access: 20.07.2015).


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