Modern markers in diagnostics of food intolerance in infant

Written by Shumatova T.A., Shishatskaya S.N., Zernova E.S., Katenkova E.Y., Odenbakh L.A., Prihodchenko N.G.

  UDK: 616–056.25/.43–053.3–074 | Pages: 55–58 | Full text PDF | Open PDF 

Background. Despite new treatment methods and diagnostics of food intolerance in infants, it is still difficult to make a diagnosis. The research objective is to identify a diagnostics value of endogenic peptide and protein determination in blood serum and coprofiltrates in infants suffering from food intolerance (FI).
Methods. There were examined 30 infants with allergic enteropathy (cow’s milk protein intolerance) and 30 infants with secondary lactase deficiency at age 6–12 months (control group – 20 healthy infants). Zonulin, eosinophilic cationic protein, β-defensin 2, and transthyretin content were determined in coprofiltrates; fatty acidbinding proteins, and membrane permeability-increasing protein.
Results. Twofold increase in coprofiltrates content of β-defensin 2, and zonulin says for cow’s milk protein intolerance. Intestinal absorption abnormality were attended by intestinal and liver fatty acid-binding proteins increase (max level was registered at allergic enteropathy) in blood serum. Membrane permeability-increasing protein level occurred to be an informative measure of cow’s milk protein intolerance.
Conclusions. Achieved results broaden the vision about the pathogenesis of food intolerance. The use of these markers will improve the diagnostics, and avoid aggressive approach in the range of cases. Implementation of these methods will improve the diagnostics, disease prognosis and possibility of adequate therapy of food intolerance in infants.

Links to authors:

T.A. Shumatova, S.N. Shishatskaya, E.S. Zernova, E.Y. Katenkova, L.A. Odenbakh, N.G. Prihodchenko
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

1. Akberova D.R. The role of intestinal permeability in chronic parenchymal hepatic diseases // Practical Medicine. 2015. Vol. 2, No. 4. P. 10–12.
2. Kazyukova T.V. Allergy to cow›s milk protein: clinical nutrition strategy of choice (literature review) // Effective Pharmacotherapy. Pediatrics. 2013. No. 3. P. 31–34.
3. Kozulina I.E., Kurbacheva O.M., Ilina N.I. Allergy today. Analysis of new epidemiological data // Russian Allergological Journal. 2014. No. 3. P. 3–4.
4. Makarova S.G., Namazova-Baranova L.S., Borovik T.E. [et al.]. Gastrointestinal manifestations of allergy to cow›s milk protein in children // Medical Board. 2014. No. 1. Р. 28–34.
5. Mamchur M.I., Levykh A.E. Defensins are endogenous peptides with anti-infective and anti-tumor properties // Taurian Medical and Biological Bulletin. 2012. Vol. 15, No. 2. P. 315–321.
6. Minaev S.V., Isaeva A.V., Tovkan E.A. [et al.]. Prognostic significance of bactericidal protein that increases the permeability of cells in newborns with congenital pathology of the gastrointestinal tract // Medical Bulletin of North Caucus. 2014. Vol. 9, No. 2. P. 116–119.
7. Pampura A.N. The principles of diet therapy of young children suffering from food allergies // Russian Allergological Journal. 2010. No. 1. P. 57–65.
8. Shumatova T.A., Prikhodchenko N.G., Grigoryan L.A. Morphofunctional evaluation of gastric mucosa condition in children with food intolerances // Pacific Medical Journal. 2014. No. 1. P. 28–30.
9. Shumatova T.A., Prikhodchenko N.G., Efremova I.V. [et al.]. Clinical and laboratory analysis of enteral nutritional support of children with severe disorders of intestinal absorption // Pacific Medical Journal. 2013. No. 1. P. 38–41.
10. Shumilov P.V., Dubrovskaya M.I., Yudina O.V. [et al.]. Eosinophilic inflammatory gastrointestinal disease and food allergies in children // Practical Medicine. 2010. No. 3. P. 16–25.
11. Ando Y. Transthyretin: it›s miracle function and pathogenesis // Japan. J. Clin. Pathol. 2009. Vol. 57, No. 3. P. 228–235.
12. Fasano A. Zonulin and ist regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer // Physiol. Rev. 2011. Vol. 91. Р. 151–175.
13. Funaoka Н., Kanda Т., Fujii Н. [et al.] Intestinal fatty acid-binding protein (I-FABP) as a new biomarker for intestinal diseases // The Japanese Journal Of Clinical Pathology. 2010. Vol. 58, No. 2. P. 162–168.
14. Gajda A.M., Storch J. Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine // PLEFA. 2015. Vol. 93. Р. 9–16.
15. Ozdemir O., Mete E., Catal F. [et al.] Food intolerances and eosinophilic esophagitis in childhood // Dig. Dis. Sci. 2009. Vol. 54, No. 1. Р. 8–14.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.