Clinical-functional features of cardio-vascular complications in chronic glomerulonephritis

Written by Murkamilov I.T., Kaliev R.R., Kaliev K.R., Aitbaev K.A.

  UDK: 616.1-06:616.611-002-036.12 | Pages: 41–46 | Full text PDF | Open PDF 


Background. Studies in experimental and clinical nephrology found mechanisms of development, and substantiated some ways to treat diseases of the cardiovascular system in anemia caused by chronic kidney disease. Nevertheless, the number of studies dedicated to the defeat of the cardiovascular system in patients with chronic glomerulonephritis (CGN) at a predialysis stage is still small, and the results are inconsistent.
Methods. The study included 631 patients aged 16 to 65 years, with CGN in the predialysis stage of the disease. According to various aspects of the defeat of the cardiovascular system it was compared clinical and laboratory surveillance data of patients with and without anemia.
Results. Among patients with CGN and anemia were significantly more frequent coronary heart disease, supraventricular and ventricular arrhythmias, and heart failure than in patients suffering from CGN without anemia.
Conclusions. Structural changes in the cardiovascular system in patients with CGN develop in the predialysis period of the disease and the most common variants of defeat are coronary heart disease, arrhythmias and heart failure. The existence of anemia with cardiovascular complications in CGN is associated with deterioration of renal nitrogen-excretive function.

Links to authors:
I.T. Murkamilov¹, R.R. Kaliev¹, K.R. Kaliev², K.A. Aitbaev²
1 Kyrgyz State Medical Academy named after I.K. Akhunbaev (92 Akhunbaev St. Bishkek 720020 Kyrgyz Republic),
2 National Center of Cardiology and Internal Medicine named after academician Mirsaid Mirrakhimov (3 Togolok Moldo St. Bishkek 720040 Kyrgyz Republic)

1. Belenkov Yu.N., Mareev V.Yu. The principles of sustainable treatment of cardiac failure. М.: Media-Medica, 2001. 266 p.
2. Milovanova L.Yu., Nikolaev A.Yu., Kozlova T.A. [et al]. Prognostic value of early correction of anemia in patients with chronic renal failure // Nephrology and Dialysis. 2004. Vol. 6, No. 1. P. 54–57.
3. Mukhin N.A., Fomin V.V., Moiseev S.V. [et al]. Sudden cardiac death in patients with chronic renal disease // Clinical Nephrology. 2014. No. 3. P. 43–47.
4. Colin D., Jonathan N., Richard P. [et al]. Arterial stiffness in chronic kidney disease: causes and consequences // Heart. 2010. Vol. 96. P. 817–823.
5. Fox C.S., Matsushita K., Woodward M. [et al]. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis of 1 024 977 individuals // Lancet. 2012. Vol. 380. P. 1662–1673.
6. Hernandez G.T., Sippel M., Mukherjee D. Interrelationship between chronic kidney disease and risk of cardiovascular diseases // Cardiovascular Hematological Agents in Medicinal Chemistry. 2013. Vol. 11. P. 38–43.
7. Levey A.S., de Jong P.E., Coresh J. [et al]. The definition, classification, and prognosis of chronic kidney disease: a KDIGO controversies conference report // Kidney Int. 2011. Vol. 80. P. 17–28.
8. Mases A., Sabaté S., Guilera N. Preoperative estimated glomerular filtration rate and the risk of major adverse cardiovascular and cerebrovascular events in non-cardiac surgery // Br. J. Anaesth. 2014. Vol. 113, No. 4. P. 644–651.
9. Matsushita K., Sang Y., Ballew S. H. [et al]. Cardiac and kidney markers for cardiovascular prediction in individuals with chronic kidney disease: the atherosclerosis risk in communities study arterioscler // Thromb. Vasc. Bio. 2014. Vol. 34. P. 1770–1777.
10. Matsushita K., Sang Y., Ballew S. H. [et al]. Subclinical Atherosclerosis Measures for Cardiovascular Prediction in CKD // JASN. 2014& URL: http://atvb.ahajournals.org/content/ 34/8/1770.full?sid=bf83bc7b-16aa-4551-9153-1bc7fb35ff9f (дата обращения: 10.10.2014).
11. Narula A.S., Jha V., Bali H.K. [et al]. Cardiac arrhythmias and silent myocardial ischemia during hemodialysis // Ren. Fail. 2000. Vol. 22, No. 3. P. 355–368.
12. Qi-Zhe Cai, Xiu-Zhang Lu, Ye Lu, Angela Yee-Moon Wang. Longitudinal changes of cardiac structure and function in CKD(CASCADE Study) // JASN. 2014. Vol. 25, No. 7. P. 1599– 1608.
13. Sreekanth V., Crystal C. Laura P. [et al]. Apparent treatmentresistant hypertension and chronic kidney disease: another cardiovascular-renal syndrome? // Advances in Chronic Kidney Disease. 2014. Vol. 21, No. 6. P. 489–499.


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