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Evaluation of clinical application of Silodosin in men with lower urinary tract symptoms on a background of benign prostatic hyperplasia

Written by Kirilenko E.A., Onopko V.F.

  UDK: 616.65-007.61-06:616.65-002-085.214.3 | Pages: 68–70 | Full text PDF | Open PDF 

Annotation:
Background. The research objective is to evaluate the clinical efficacy and safety of α1-blocker silodosin in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).
Methods. 26 ambulatory patients aged 52–87 with LUTS in BPH received Silodosin (8 mg daily) for 8 weeks. Treatment efficacy was assessed by IPSS, quality of life by the index of QoL.
Results. After 4 weeks, the total score on the IPSS decreased by 33 % and by 8th week – 54.5 % of the original. The average sum of scores on QoL also decreased by 27 % in the 4th week of observation, and by 51.2 % – to the end of the study. The overall incidence of adverse events was 19.2 % (5 patients).
Conclusions. Effective impact on LUTS with minimal negative effects on the cardiovascular system, and high uroselektiveness allow assigning Silodosin as monotherapy or as part of a combined treatment of BPH.

Links to authors:

E.A. Kirilenko, V.F. Onopko
Irkutsk State Medical University (1 Krasnogo Vosstaniya St. Irkutsk 664003 Russian Federation).


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