Evaluation of clinical application of Silodosin in men with lower urinary tract symptoms on a background of benign prostatic hyperplasia

Written by Kirilenko E.A., Onopko V.F.

  UDK: 616.65-007.61-06:616.65-002-085.214.3 | Pages: 68–70 | Full text PDF | Open PDF 

Background. The research objective is to evaluate the clinical efficacy and safety of α1-blocker silodosin in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).
Methods. 26 ambulatory patients aged 52–87 with LUTS in BPH received Silodosin (8 mg daily) for 8 weeks. Treatment efficacy was assessed by IPSS, quality of life by the index of QoL.
Results. After 4 weeks, the total score on the IPSS decreased by 33 % and by 8th week – 54.5 % of the original. The average sum of scores on QoL also decreased by 27 % in the 4th week of observation, and by 51.2 % – to the end of the study. The overall incidence of adverse events was 19.2 % (5 patients).
Conclusions. Effective impact on LUTS with minimal negative effects on the cardiovascular system, and high uroselektiveness allow assigning Silodosin as monotherapy or as part of a combined treatment of BPH.

Links to authors:

E.A. Kirilenko, V.F. Onopko
Irkutsk State Medical University (1 Krasnogo Vosstaniya St. Irkutsk 664003 Russian Federation).

1. Apolokhin O.I., Sivkov A.V., Katibov M.I. [et al.]. Preliminary results of the landmark complex of standardized diagnostic and treatment programs for BPH // Experimental and Clinical Urology. 2014. No. 1. P. 4–8.
2. Vishnevskiy A.E., Lukyanov I.V., Markov A.V. Preferences in selecting patients alpha blockers in the treatment of urinary disorders in patients // Experimental and Clinical Urology. 2013. No. 2. P. 51–55.
3. Danilov V.V., Vasilchenko A.V., Danilova T.I. [et al.]. Pharmacological urodynamic noninvasive investigations in patients with BPH // Urology. 2010. No. 6. P .16–19.
4. Lokshin K.L. The possibilities of modern α1-blockers in the treatment of patients suffering from benign prostatic hyperplasia // RMJ. Urology. 2011. No. 16. P. 1010.
5. Sivkov A.V., Keshishev N.G., Romikh V.V. [et al.]. The efficacy of silodosin in patients with severe symptoms of dysfunction of the lower urinary tract caused by benign prostatic hyperplasia // Experimental and Clinical Urology. 2013. No. 4. P. 71–74.
6. Surikov V.N. Comparative evaluation of efficacy and safety of alpha 1-blockers in patients with benign prostatic hyperplasia: thesis abstract, PhD. М., 2004. 34 p.
7. Cheppel K. Lower urinary tract symptoms: not only prostate // Urology Today. 2013. No. 6. P. 1–3.
8. Yarovoy S.K. Silodosin - new drug group of selective alphablockers // Experimental and Clinical Urology. 2012. No. 3. P. 57–62.
9. Chapple C.R., Montorsi F., Tammela T.L. [et al.]. Silodosin therapy for lower urinary tract symptoms in men with suspect benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo - and active-controlled clinical trial performed in Europe // Eur. Urol. 2011. No. 59. Р. 342–352.
10. EAU Recommendations on Treatment of Non–neurogenic Male LUTS, 2011 / Eds. M. Oelke (chairman), A. Bachmann, A. Descazeaud [et al.]. URL: http://www.uroweb.org/gls/pdf/12_Male_ LUTS.pdf (дата обращения: 25.09.2015).
11. Kok E.T., Schouten B.W., Bohnen A.M. [at al.] Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study // J. Urol. 2009. Vol. 181, No. 2. Р. 710–716.
12. Lepor H. The evolution of alfa-blockers for the treatment of benign prostatic hyperplasia // Rev. Urol. 2006. Vol. 8, No. 4. P. 3–9.
13. Oelke M., Bachmann A., Descazeaud A. [et al.]. ЕАU guidelines on the treatment and follow-up of non-neurogenic male LUTS including benign prostatic obstruction // Eur. Urol. 2013. Vol. 64, No. 1. Р. 118–140.
14. Oelke M., Burger M., Castro-Diaz D. [et al.]. Diagnosis and medical treatment of lower urinary tract symptoms in adult men: applying specialist guidelines in clinical practice // BJU International. 2011. Vol. 110. Р. 710–718.
15. Rosen R., Altwein J., Boyle P. [at al.] Lower urinary tract symptoms and male sexual dysfunction the mutinatio-nalsurvey of the aging male // Eur. Urol. 2003. Vol. 44, No. 6. Р. 637–649.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.