The role of mast cells in the pathogenesis of autoimmune thyroid diseases

Written by Zdor V.V., Geltser B.I., Markelova E.V.

  UDK: 616.411-097.3:612.018.2 DOI: 10.17238/PmJ1609-1175.2016.3.11–14 | Pages: 11–14 | Full text PDF | Open PDF 


This literature review describes the role of cells of innate immune system, mast cells, in the pathogenesis of autoimmune thyroid diseases. In recent years a large number of articles were about studying new immune properties of mast cells and, in particular, their effect on T-cells’ functions through secretion of various cytokines. However, the articles that have been analyzed do not fully clarify an assumed ability of mast cells to directly activate T-cells through autoantigen presentation. Possible MHC class II expression by mast cells also remains disputable. This review considers a hypothesis that mast cells can control functional activity of immune cells and thyroid, provided they have appropriate effect. At present this assumption is considered to be a mechanism that triggers the pathogenesis of autoimmune thyroid diseases.

Links to authors:

V.V. Zdor, B.I. Geltser, E.V. Markelova
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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