Pathomorphogenesis of idiopathic colitis

Written by Kaminskiy Yu.V., Matveev Yu.A., Matveeva N.Yu.

  UDK: 616.344-002-091: 616.344-002-031.84-091 DOI: 10.17238/PmJ1609-1175.2016.3.42–45 | Pages: 42–45 | Full text PDF | Open PDF 


Objective. The research objective is to determine structural features of development of idiopathic colitis. Methods. Morphological, histochemical, immunological histochemical and morphometric tests were conducted adapted from 15 autopsies and 15 biopsies of colon of patients suffering from inflammatory intestine diseases. Results. In the area of pathological changes of the colon revealed numerous cells with apoptosis and necroptosis signs, and specific perifocal inflammatory reaction in the upper third of the mucosal crypts. It was determined high levels of expression of p53, Bax and PUMA, and low level villin in epithelial cells. By increasing the production of villin, expression of proapoptotic factors drastically reduced. Conclusions. Apoptosis and necroptosis of intestinal epithelium advanced or premature as a result of the villin deficiency, cause chronic non-infectious colitis. Development of subsequent inflammation with various cell infiltration and cytokine imbalance contributes to chronic process and the creation of precancerous background.

Links to authors:

Yu.V. Kaminskiy, Yu.A. Matveev, N.Yu. Matveeva
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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