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Some results and new trends in the development of studies on marine biologically active metabolites

Written by Stonik V.A.

  UDK: 615.32: 577.121 | Pages: 16–18 | Full text PDF | Open PDF 

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This article represents a lecture at the International Conference “The future of modern medicine in the East-West medical perspective”, which has been held at the Pacific State Medical University (Vladivostok) on October 3, 2016. Scientists from more than 40 countries are studying marine bioactive metabolites. Results of these investigations have been described in almost ten thousands scientific articles containing the information about 27 thousands low molecular weight natural compounds. Near a dozen effectively acting drugs, created on the basis of these metabolites, has been applied in different fields of medicine, including oncology, cardiology, and ophthalmology. Recent years new trends have appeared at the interface between natural products chemistry, cellular biology, microbiology, molecular genetics and fundamental medicine. Some results obtained in the framework of these trends are discussed in this article. Several examples of the studies on natural products, carried out at G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences, were shown in order to illustrate the achievements, connected with the search for, isolation, structure elucidation, and biological activity of marine natural products.

Links to authors:

V.A. Stonik
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS (159 100 Let Vladivostoku Ave. Vladivostok 690022 Russian Federation)


1. Popov A.M., Krivoshapko O.N., Tsybulskiy A.V. [et al.]. Therapeutic activity of ‘Kourohitin’ drug in modeling allergic dermatitis // Journal of Biopharmaceuticals. 2014. Vol. 7. P. 24–30.
2. Aminin D.L., Gorpenchenko T.Y., Bulgakov V.P. [et al.]. Triterpene glycoside cucumarioside A2-2 from sea cucumber stimulates mouse immune cell adhesion, spreading, and motility // Journal of Medicinal Food. 2011. Т. 14. P. 594–600.
3. Blunt J.W., Copp B.R., Keyzers R.A. [et al.]. Marine natural products // Nat. Prod. Rep. 2014. Т. 31. P. 160–258.
4. Blunt J.W., Copp B.R., Keyzers R.A. [et al.]. Marine natural products // Nat. Prod. Rep. 2016. Т. 33. P. 382–431.
5. Fieseler L., Horn M., Wagner M., Hentschel U. Discovery of the novel candidate phylum Poribacteria in marine sponges // Appl. Environ. Microbiol. 2004. Т. 70. P. 63724–63732.
6. Kalinovskaya N.I., Romanenko L.A., Kalinovsky A.I. [et al.]. A new antimicrobial and anticancer peptide producing by the marine deep sediment strain “Paenibacillus profundus” sp. nov. Sl 79 // Natural Product Communication. 2013. Т. 8. P. 381–384.
7. Molinski T.F. Microscale methodology for structure elucidation of natural products // Curr. Opinion Biotechn. 2010. Т. 21. P. 19–826.
8. Montaster R., Luesch H. Marine natural products: a new wave of drugs? // Future Med. Chem. 2011. Т. 3. С. 1475–1489.
9. Seo D.Y., McGregor R.A., Noh S.J. [et al.]. Echinochrome A improves exercise capacity during short-term endurance training in rats // Marine Drugs. 2015. Т. 13. P. 5722–5731.
10. Silchenko A.S., Kalinovsky A.I., Avilov S.A. [et al.]. Kolgaosides A and B, two new triterpene glycosides from the Arctic deep water sea cucumber Kolga hyalina (Elasipodida: Elpidiidae) // Nat. Prod. Commun. 2014. Т. 9. P. 1259.
11. Stonik V.A. Studies on marine natural products as a road to new drugs // Herald of the Rus. Acad. Sci. 2016. Т. 86. P. 217–225.
12. Zhuravleva O.I., Sobolevskaya M.P., Afiyatullov Sh.Sh. [et al.]. Sargassopenillines A–G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum // Marine Drugs. 2014. Т. 12. P. 5930–5938.
13. Zhuravleva, O.I., Kirichuk, N.N., Denisenko, V.A. [et al.]. New diorcinol J produced by co-cultivation of marine fungi Aspergillus sulphureus and Isaria feline // Chem. Nat. Compd. 2016. Т. 52. P. 227–228

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