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Immune mechanisms of miscarriage and infertility at pollinosis and possible ways of their correction

Written by Tsyvkina G.I., Grigoreva N.V., Lutsenko G.A., Petrova O.V.

  UDK: 618.177/.39-06:616-056.43-085 | Pages: 22–25 | Full text PDF | Open PDF 

Annotation:

Objective. Immune mechanisms involved in the pathogenesis of recurrent miscarriage and infertility. Despite the fact that fetal cells carry antigens of both mother and father, there is ‘an immunological paradox’ of pregnancy associated with the occurrence of immunological tolerance.
Methods. The object of study – 22 women with pollinosis who had episodes of miscarriage in the medical history and 31 women with pollinosis, but without a burdened obstetric history (control group – 20 women without aggravated allergic and obstetric history).
Results. Changes in immunological parameters in patients with pollinosis had a similar clinical picture. However, in the group with recurrent miscarriage noted high activity of NK-cells with a cytotoxic phenotype. In women without the burdened obstetric history NK-cells were defined within the normal range during pregnancy and changed their phenotype to immunosuppressive one.
Conclusions. A preconception period program in women having had episodes of miscarriage in their medical history should cover the pollinosis screening, and in women with detected pollinosis should detect the NK-cells levels and cytoxic T lymphocytes assessing their functional activity.

Links to authors:

G.I. Tsyvkina, N.V. Grigoreva, G.A. Lutsenko, O.V. Petrova
Regional Clinical Center of Modern Medical Care (30/37 Uborevicha St. Vladivostok 690000 Russian Federation)


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