Trophic factors of bone growth, their morphogenetic characterization and clinical significance

Written by Kostiv R.E., Kalinichenko S.G., Matveeva N.Yu.

  UDK: 611.018.4:612.753:616.7(048.8) | Pages: 10–16 | Full text PDF | Open PDF 

The literature review dedicated to regeneration mechanisms of bone tissue. Summarized the data on topochemistry and functions of morphogenetic and growth factors, their participation in the regulation of the regenerative processes on different levels of the fracture union. Given the detailed critical overview of the technologies of production and clinical use of morphogenetic proteins on the basis of recombinant technologies of gene engineering with reparative osseogenesis. One of the most promising ways of increasing the osteoinductive properties of biomaterials and bone tissue regeneration control process is the creation of various composites having osteoinductive and osteoconductive properties, containing growth factors, and at the same time performing the role of the osteogenic matrix.

Links to authors:

R.E. Kostiv, S.G. Kalinichenko, N.Yu. Matveeva
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 6900950 Russian Federation)

1. Bartov M.S., Karyagina A.S., Gromov A.V. [et al.]. Osteoplastic drugs of a new generation ‘Gamalant’ containing growth factors and bone regeneration // The Department of Traumatology and Orthopedics. 2012. No. 2. P. 21–25.
2. Berchenko G.N. Biology of bone fractures healing and the influence of bio composite nanostructured material Kollapan on activation of reparative osteogenesis. // Medical Alphabet. Hospital. 2011. No. 1. P. 14–19.
3. Zaytsev V.V., Karyagina A.S., Lunin V.G. Bone morphogenetic proteins (BMPs): general characteristics and prospects of clinical application in traumatology and orthopedics. // Reporter of Traumatology and Orthopedics named Priorov. 2009. No. 4. P. 79–84.
4. Kalinichenko S.G., Schava S.P., Matveeva N.Yu. Angiogenic and cytoprotective influence of basic fibroblast growth factor in the focus of experimental cerebral ischemia // Pacific Medical Journal. 2009. No. 2. P. 66–69.
5. Balaji A., Alam N. Bone morphogenetic proteins. LAP LAMBERT Academic Publishing, 2012. 60 p.
6. Bishop G.B., Einhorn T.A. Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery // International Orthopaedics. 2007. Vol. 31. P. 721–727.
7. Chen G., Deng C., Li Y.P. TGF-β and BMP Signaling in osteoblast differentiation and bone healing // Int. J. Biol. Sci. 2012. Vol. 8. P. 272–288.
8. Einhorn T.A. Bone healing: little secrets. // Clinical cases in mineral and bone metabolism. 2011. Vol. 8. P. 17–20.
9. Fassbender M., Minkwitz S., Strobel C. et al. Stimulation of bone healing by sustained BMP-2 delivery // Int. J. Mol. Sci. 2014. Vol. 15. P. 8539–8552.
10. Giannoudis P.V., Einhorn T.A. Bone morphogenetic proteins: applications in orthopaedic and trauma surgery. Elsevier, 2010. 177 p.
11. Govender S., Csimma C., Genant H.K. [et al.]. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients // J. Bone Jt. Surg. Am. 2002.Vol. 84. P. 2123–2134.
12. Granjeiro J.M., Oliveira R.C., Bustos-Valenzuela J.C. [et al.]. Bone morphogenetic proteins: from structure to clinical use // Braz. J. Med. Biol. Res. 2005. Vol. 38. P. 1463–1473.
13. Hollinger J.O., Hart C.E., Hirsch S.N. [et al.]. Recombinant human platelet-derived growth factor: biology and clinical applications // J. Bone Joint Surg. (Am). 2008. Vol. 90. P. 48–54.
14. Jain A.P., Pundir S., Sharma A. Bone morphogenetic proteins: the anomalous molecules // Journal of Indian Society of Periodontology. 2013. Vol. 17, No. 5. P. 583–586.
15. Kanakaris N.K., Calori G.M., Verdonk R. [et al.]. Application of BMP-7 to tibial non-unions: A 3-year multicenter experience // Injury. 2008. Vol. 39. P. 83–90.
16. Kanakaris N.K., Mallina R., Calori G.M. [et al.]. Use of bone morphogenetic proteins in arthrodesis: clinical results // Injury. 2009. Vol. 40 (Suppl. 3). P. 62–66.
17. Marsell R., Einhorn T.A. The biology of fracture healing // Injury. 2011. Vol. 42, No. 6. P. 551–555.
18. Nauth A., Ristiniemi J., McKee M.D. [et al.]. Bone morphogenetic proteins in open fractures: past, present and future // Injury. 2009. Vol. 40 (Suppl. 3). P. 27–31.
19. Shimer A.L., Oner F.C., Vaccaro A.R. Spinal reconstruction and bone morphogenetic proteins: open questions // Injury. 2009. Vol. 40 (Suppl. 3). P. 32–38.
20. Simpson A.H.R.W., Mills L., Noble B. The role of growth factors and related agents in accelerating fracture healing // JBJS (Br). 2006. Vol. 88, No. 6. P. 701–705.
21. Solheim E. Growth factors in bone. // International Orthopaedics. 1998. Vol. 22. P. 410–416.
22. Urist M.R. Bone: formation by autoinduction // Sciens. 1965. Vol. 150. P. 893–899.
23. Wozney J.M., Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair // Clin. Orthop. Relat. Res. 1998. Vol. 346. P. 26–37.
24. Yu Y.Y., Lieu S., Lu C., Colnot C. BMP 2 stimulates endochondral ossification by regulating periostal cell fate during bone repair // Bone. 2010. Vol. 47, No. 1. P. 65–73.
25. Zimmermann G., Wagner C., Scheckenbecher K. [et al.]. Treatment of tibial shaft non-unions: bone morphogenetic proteins versus autologous bone graft // Injury. 2009. Vol. 40 (Suppl. 3). P. 50–53.
26. Zwingenberger S., Nich C., Valladares R.D. [et al.]. Recommendations and considerations for the use of biologics in orthopedic surgery // Bio Drugs. 2012. Vol. 26, No. 4. P. 245–256.


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