Biomarkers of subchondral bone remodeling in osteoarthritis

Written by Kabalyk M.A.

  UDK: 616.72-018.3-002-07:612.018 | Pages: 37–41 | Full text PDF | Open PDF 

Osteoarthritis – the most widespread and socially significant diseases of the musculoskeletal system, the main problem is the lack of treatment which diagnostic and prognostic markers of early stages of the disease. The purpose of this review is an analysis of biomarker degradation of the subchondral bone in osteoarthritis. The article reviews subphenotypic molecules – cholecalciferol and parathyroid hormone, and biological substances produced by osteoblasts at various stages of bone differentiation. The review of the literature suggests an important diagnostic value of a variety of biological substances in osteoarthritis, among which the most interesting are osteocalcin, calcitonin, fibrillar protein degradation products of bone and cartilage matrix, cholecalciferol. It appears promising study the diagnostic value of biomarkers disclosed that a significant degree will contribute to the expansion of the diagnostic and prognostic tools, and allow more detailed assessment of a heterogeneous population of patients with osteoarthritis.

Links to authors:

M.A. Kabalyk
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation)

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