The role of matrix metalloproteinase system in the primary open angle glaucoma patient

Written by Khokhlova A.S., Markelova E.V., Filina N.V., Ovchinnikova O.V., Vaeva T.G., Kabieva A.A.

  UDK: 617.7-007.681-074:577.152 | Pages: 32–34 | Full text PDF | Open PDF 


Objective. The objective of the study is to search for immunological predictors of the rate of progression of glaucoma optic neuropathy reflecting the state of the extracellular matrix. Methods. In 75 patients with primary open-angle glaucoma (POAG) of stages I-IV in the tear fluid were determined the content of matrix metalloproteinases (MMPs) 8 and 9 and their tissue inhibitor (TIMP-1). The observation period is 1 year. Results. MMP-9 and MMP-8 levels and their ratio with TIMP-1 significantly increased with a rapid progression of POAG. The ratio of MMP-9 / TIMP-1 with rapid disease progression was 2.5- 3 times higher than with slow progression and 3.5 times higher than with stabilized POAG. Conclusions. The role of the MMPs system and their relationship to tissue inhibitors in the pathogenesis of POAG is confirmed. The data obtained will make it possible to recommend a study of the performance of the extracellular matrix for the detection of the risk of rapid progression of glaucoma optic neuropathy and the connection of more active therapy.

Links to authors:

A.S. Khokhlova1, E.V. Markelova1, N.V. Filina1, O.V. Ovchinnikova1,
T.G. Vaeva2, A.A. Kabieva2
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 Vladivostok Diagnostic Center (169/171 Svetlanskaya St. Vladivostok 690001 Russian Federation)

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