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Intravenous immunoglobulins as adjuvant therapy in patients with sepsis

Written by Shumatov V.B., Lazanovich V.A., Pavlov V.A., Ermakova N.D., Prosecova E.V.

  UDK: 616.94-085.37 | Pages: 42–45 | Full text PDF | Open PDF 

Annotation:

Objective. Treatment and prevention of postoperative complications in patients with purulent-septic pathology remain one of the most urgent problems of modern surgery. One of the groups of drugs that are used as an adjuvant therapy for surgical sepsis are intravenous immunoglobulins (IVIG). Methods. We observed 56 patients with sepsis, which were divided into 3 groups. 1st group (25 patients) received traditional treatment, 2nd group (14 patients) received standard IVIG (Ig G) in addition to traditional therapy, 3rd group (17 patients) in addition to conventional therapy received enriched IVIG (Ig M+Ig A). Results. Comparative assessment of the combination of intravenous immunoglobulin’s and traditional therapy indicated the clinical effectiveness of IVIG therapy, which results in reducing the severity of systemic inflammation, the severity of the disease and the mortality in patients with surgical sepsis. Conclusion. Thus, after analyzing the results obtained, it was shown that it is advisable to include IVIG in complex therapy of patients with surgical sepsis.

Links to authors:

V.B. Shumatov1, V.A. Lazanovich2, V.A. Pavlov3, N.D. Ermakova1,
E.V. Prosecova1
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 Primorye Regional Clinical Hospital No. 1 (57 Aleutskaya St. Vladivostok 690091 Russian Federation),
3 Vladivostok Clinical Hospital No. 2 (57 Russkaya St. Vladivostok 690105 Russian Federation)


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