The role of pathogenicity factors of Enterococcus faecalis in the development of pyelonephritis in children

Written by Zaitseva E.A., Krukovich E.V., Melnikova E.A., Luchaninova V.N., Komenkova T.S., Vaysero N.S.

  UDK: 616.61-002.3-06:616.98:579.86 | Pages: 58–61 | Full text PDF | Open PDF 


Objective. In recent years, the frequency of occurrence of Enterococcus faecalis as an etiological factor of infection of the urinary system has increased, according to different authors, up to 14.2– 16 %. It has been established that enterococci synthesize a large number of virulence factors that contribute to the development of the infectious process. Methods. 57 cultures of E. faecalis isolated from the urine of children with a urinary tract pathology were studied, the cases were analyzed. Results. Cultures of enterococci showed a phenotypic heterogeneity of biological properties, including virulence factors. It was established that the intoxication syndrome prevailing in the clinical picture is caused by a complex of pathogenic factors of fecal enterococcus causing toxic tissue damage. Conclusions. A correlation between the degree of adhesion, hemolytic, gelatinase and lecithinase activity was revealed with symptoms associated with upper urinary tract damage, which indicates the importance of microbial adhesion and certain pathogenicity factors of E. faecalis in the pathogenesis of the infectious inflammatory process.

Links to authors:

E.A. Zaitseva1, E.V. Krukovich1, E.A. Melnikova1, 2,
V.N. Luchaninova3, T.S. Komenkova1, N.S. Vaysero
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690950 Russian Federation),
2 1 Regional Children’s Clinical Hospital (27 Ostryakova Ave. Vladivostok 690078 Russian Federation),
3 North-Western State Medical University named after I.I. Mechnikov (41 Kirochnaya St. Saint Petersburg 191015 Russian Federation)

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