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Analysis of a new nootropic composition based on Phenotropil and Gammalone

Written by Markova O.M., Vystavkin E.A.

  UDK: 615.214.31.07 | Pages: 63–65 | Full text PDF | Open PDF 

Annotation:
Objective. The study objective is the development of methods for the quantitative analysis of a new nootropic composition containing Phenotropil and Gammalone. Methods. For quantitative determination of Phenotropil, ultraviolet spectrophotometry was used, for Gammalone titration was used. Results. The relationship between the optical density of the solution and the content of Phenotropil in it, the volume of the titrant and the hinge of the Gammalone was linear in the Phenotropil content and in the range from 0.01 to 0.1 %, and of the Gammalone from 0.1 to 0.5 g. Conclusions. The results of the validation evaluation of the quantitative determination of Gammalone and Phenotropil and the model mixture showed that these techniques allow reliable determination of the starting substances in their joint presence.

Links to authors:

O.M. Markova1, E.A. Vystavkin2
1 Рyatigorsk Medical Pharmaceutical Institute (11 Kalinina St. Pyatigorsk 357500 Russian Federation),
2 Military Medical Academy named after S.M. Kirov (37a Akademika Lebedeva St. Saint Petersburg 194044 Russian Federation)


1. Aleksandrovskiy Yu.A., Avedisova A.S., Akhapkina V.I. Clinical and physiological effectiveness assessment of nootropic drug fenotropil in psychiatry clinic // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 59.
2. Arzamstsev A.P. Pharmaceutical chemistry: textbook. М.: GEOTAR- Media, 2004. 640 p.
3. Akhapkina V.I. Experimental and clinical pharmacology of the drug fenotropil // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 70.
4. Akhapkina V.I., Voronina T.A. Comparative characteristics of nootropic activity of the drug fenotropil // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 70.
5. Berlyand A.S., Akhapkina V.I. Results of pharmacokinetic studies of the nootropic drug fenotropil // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 87.
6. Vakhov V.P., Akhapkina V.I. Use of fenotropil in people working in stressful extreme conditions // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 603.
7. Voloshin V.M., Akhapkina V.I. The effectiveness of small doses of fenotropil in general theoretical practice // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 112.
8. State Pharmacopoeia of the USSR. 10th edition. М.: Meditsina, 1968. 1080 p.
9. State Pharmacopoeia of the USSR. 11th edition., iss. 1. М.: Meditsina, 1987. 369 p.
10. State Pharmacopoeia of the USSR 11th edition., iss. 2. М.: Meditsina, 1990. 400 p.
11. Ivanets N.N., Akhapkina V.I. The use of fenotropil in patients with chronic alcohol abuse // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 169.
12. Kolosova S.A., Vorobeva O.V., Akhapkina V.I. The results of clinical studies of the use of fenotropil in the treatment of asthenic disorders of psychogenic origin // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 194.
13. Krasnov V.N., Kokhanov V.P., Akhapkina V.I. Fenotropil as an adaptogenic and nootropic medicine // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М, 2004. P. 615.
14. Malyugin V.N., Cherepanov E.G., Akhapkina V.I. Study of the effect of the phenothyro drug on the functional state and performance in the process of training // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2004. P. 617.
15. Spasenkov B.A., Akhapkina V.I., Spasenkov M.G. The use of a nootropic drug phenotropil in the complex therapy of dyscirculatory encephalopathy // Reports abstracts of the ХI Russian national congress ‘Man and Medicine’. М., 2014. P. 349.

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