Hemodynamics of the brain: glutamatergic system and the cycle of nitric oxide in the regulation of cerebral circulation. New concept

Written by Reutov V.P., Sorokina E.G., Samosudova N.V., Zakharchuk N.V.

  UDK: 612.824.1:612.135: 616.8-091.81:546.172.6-31 | Pages: 37–45 | Full text PDF | Open PDF 


Described the role of the glutamatergic system and the cycle of nitric oxide in the regulation of cerebral circulation. According to the ideas developed in the article, the cycle of nitric oxide, which ensures the continuous supply and regeneration of the bulk neurotransmitter of NO for the mechanisms of glutamatergic and NO-ergic transmission, plays an important role of the integrating element in the functional brain system including neurons, glia and capillaries. The effectiveness of this mechanism repeatedly increases under conditions of hypoxia / ischemia, when the heme-containing proteins pass into the deoxy form and begin to restore NO2 – ions into NO.

Links to authors:

V.P. Reutov1, E.G. Sorokina2, N.V. Samosudova3, N.V. Zakharchuk4
1 Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences (5a Butlerova St. Moscow 117485 Russian Federation),
2 National Scientific and Practical Center of Children’s Health (2/1 Lomonosovsky Ave. Moscow 119991 Russian Federation),
3 A.A. Kharkevich Institute for Information Transmission Problems of the Russian Academy of Sciences (19 Bolshoy Karetny Per. Moscow 101447 Russian Federation),
4 Pacific State Medical University (2 Ostryakova Ave. Vladovostok 690002 Russian Federation)

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