Application of dabigatrane and rivaroxaban in heredicial hematogenous thrombofilia

Written by Voitsekhovskiy V.V.

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Objective. The experience of using dabigartane and rivaroxaban for secondary prevention of thrombus formation in patients with hereditary hematogenous thrombophilia is considered.
Methods. Examined 65 patients with hereditary combined hematogenous thrombophilia aged from 17 to 60. 35 patients took dabigatrane (pradax), 20 patients took rivaroxaban (xarelto), 10 patients took warfarin.
Results. After the prescription of dabigatrane or rivaroxaban, no patient recurred any life-threatening thrombotic complications. When dabigatrane was used, hemorrhagic complications were not diagnosed, and only 4 people receiving rivaroxaban had nasal bleeding.
Conclusions. Dabigatrane and rivaroxaban are effective and safe drugs for antithrombotic therapy in hereditary hematogenous thrombophilia. Absence of the need for constant laboratory monitoring and extremely rare hemorrhagic complications make it possible to use them in patients living in regions remote from large medical centers.

Links to authors:
V.V. Voitsekhovskiy
Amur State Medical Academy (95 Gorkogo St. Blagoveschensk 675000 Russian Federation)

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