Molecules of cellular adhesion ICAM-1 and VCAM-1 in infectious pathology

Written by Moskalets O.V.

  UDK: 616.988–074/076:611.018.74 | Pages: 21–25 | Full text PDF | Open PDF 


Endothelial activation is an important part of immune response to an infection. Processes of leukocytes migration in the tissue of blood vessels depend on endothelium condition. With the activation of the endothelium followed by its dysfunction, there is an increase in expression on the membrane of endothelial cells of molecules of cell adhesion, in particular, the molecule of intercellular adhesion molecule 1-type (ICAM-1) and the molecule of adhesion of vascular endothelium of the 1-type (vascular cell adhesion molecule 1 – VCAM-1), which provide a strong adhesion of leukocytes to the endothelium. Soluble forms of these molecules can be considered as surrogate biomarkers of endothelial activation. The review provides the data of the world literature of changes in the expression of these biomarkers in sepsis, hemolytic-uremic syndrome, malaria, dengue haemorrhagic fever, boutonneuse fever, viral hepatitis, tuberculosis. Despite the ambiguous results it can be concluded that ICAM‑1 и VCAM-1 are promising for further study both to foresee the course and outcomes in different infectious pathology, and to develop new therapeutic strategy.

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O.V. Moskalets
Moscow Regional Scientific Research Clinical Institute (62/2 Schepkina St. Moscow 129110 Russian Federation)

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